STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Clinical trials for STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8 explained in plain language.
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Personalized cancer vaccine fights advanced liver tumors
Disease control Recruiting nowThis study is testing a new combination treatment for advanced liver cancer that cannot be removed by surgery. Doctors take a patient's own immune cells, grow and train them in a lab to attack cancer, and then inject them directly into the tumor after radiation. This personalized…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 04, 2026 05:20 UTC
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New hope for liver cancer patients after first treatment fails
Disease control Recruiting nowThis study is for people with advanced liver cancer that has spread and cannot be removed by surgery, and whose cancer has continued to grow despite receiving a specific prior immunotherapy combination. It tests whether adding an immunotherapy drug (atezolizumab) to a standard ca…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: Academic and Community Cancer Research United • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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Custom cancer vaccine designed to train your own immune system
Disease control Recruiting nowThis study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 02, 2026 14:58 UTC
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New drug duo targets tough liver cancer mutation
Disease control Recruiting nowThis study is testing whether adding a new drug called sapanisertib to an existing drug, cabozantinib, works better than cabozantinib alone for people with advanced liver cancer that has a specific genetic change (β-catenin mutation). The first part of the trial will find the saf…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 02, 2026 14:56 UTC
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Radiation boost could extend lives in aggressive liver cancer
Disease control Recruiting nowThis study is testing whether adding a precise, high-dose radiation treatment (SBRT) to standard immunotherapy drugs helps people with advanced liver cancer live longer. About 252 participants with liver cancer that has spread into major blood vessels will receive either immunoth…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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Groundbreaking pill trial offers hope for tough liver cancers
Disease control Recruiting nowThis is the first human study of an experimental oral medication called AU409 for people with advanced liver cancers or other solid tumors that have spread to the liver. The main goal is to find the safest and most effective dose by testing it in a small group of patients whose c…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Zapping tumors: wearable device tested with drugs for tough cancers
Disease control Recruiting nowThis early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Radiation 'Jump-Starts' immune system to fight spreading cancers
Disease control Recruiting nowThis study is for people with advanced gastrointestinal cancers that have spread and have stopped responding to immunotherapy. Researchers want to see if giving a short, targeted course of radiation to one tumor can 'wake up' the body's immune system to attack all the cancer, inc…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: NA • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Radiation & immune drugs team up to fight spreading liver cancer
Disease control Recruiting nowThis study is testing if a short, intense course of radiation followed by immunotherapy drugs can help control advanced liver cancer that has spread. The goal is to see if this combination helps the body's immune system better recognize and attack the cancer. It is for adults who…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: Mary Feng, MD • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Old pain pill may help new cancer drugs fight tough liver tumors
Disease control Recruiting nowThis study is testing whether adding celecoxib, a common anti-inflammatory pain medication, can help two immunotherapy drugs work better against advanced liver cancer that has spread. The goal is to see if this combination can better control the cancer's growth and spread. Resear…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New hope for rare liver cancer: triple therapy trial opens
Disease control Recruiting nowThis study is testing a combination of three drugs—nivolumab, fluorouracil, and interferon—for people with advanced fibrolamellar carcinoma, a rare liver cancer that cannot be removed by surgery. The main goals are to see if the treatment is safe and if it can shrink tumors or st…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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Scientists watch Cancer's blood supply live during surgery
Knowledge-focused Recruiting nowThis study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC