STAGE III PANCREATIC CANCER AJCC V8

This study tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The trial compares the higher-dose radiation to standard care, which may include more che…

This early-stage trial is testing whether combining a targeted drug (olaparib), an immunotherapy (durvalumab), and radiation therapy is safe for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study enrolls 18 adults who have already received…

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced or treatment-resistant solid tumors, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 participants will take part in t…

This study tests a new approach for people with pancreatic cancer that cannot be surgically removed. It combines a light-activated drug (verteporfin) with an immunotherapy (pembrolizumab) and standard chemotherapy. The goal is to see if this combination can shrink tumors better t…

This study tests a drug called M3814 (Peposertib) combined with a special type of radiation for people with locally advanced pancreatic cancer that has spread to nearby tissues. The goal is to find the safest dose and see if the combo helps stop the cancer from growing longer tha…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This early-stage trial tests whether adding leflunomide (an arthritis drug) to standard chemotherapy (gemcitabine) is safe and effective for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will take part. The goal is to find the best dose…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This study is for people with pancreatic cancer that can be removed by surgery or has spread. Researchers want to see how different drugs change tumor biology by comparing biopsies taken before and after treatment. The goal is not to cure the disease now, but to learn which drugs…