STAGE II LUNG CANCER AJCC V8

This study tests whether giving chemotherapy and immunotherapy both before and after surgery is better than only after surgery for people with stage II-IIIB non-small cell lung cancer that can be removed. About 1,100 adults will be randomly assigned to one of the two approaches. …

This study tests whether artificial intelligence can help doctors choose the right radiation dose for each person's lung tumor. About 70 adults with lung cancer or tumors that spread to the lung will receive stereotactic body radiation therapy (SBRT) with doses guided by an AI to…

This study tests whether giving two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more cancer cells in people with early-stage non-small cell lung cancer. About 60 adults with stage IB to IIIB lung cancer will receive the drug combination, then have their…

This study tests whether doing special breathing exercises before lung cancer surgery can lower the chance of problems like pneumonia or breathing trouble after the operation. About 220 people with stage I-IIIB lung cancer will either do the training or receive usual care. The go…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy after surgery helps people with stage II to IIIB non-small cell lung cancer live longer without the cancer returning. About 1,210 participants will receive either the combination or sequ…

This study tests whether giving the immunotherapy drug durvalumab after surgery can prevent early-stage non-small cell lung cancer from returning. About 306 people who have had their lung cancer completely removed will either receive durvalumab or be watched closely (the usual ap…

This study tests whether the drug canakinumab can prevent lung cancer in people who have suspicious lung nodules that haven't gone away. About 50 participants will receive the drug to see if their nodules shrink or disappear, and to track how many develop lung cancer over time. T…

This study tests whether a home-based breathing exercise program can help lung cancer survivors (stages I-III) who often struggle with shortness of breath, fatigue, and low fitness after surgery. About 100 participants will do breathing exercises regularly for several weeks. Rese…

This study tests a smarter way to give radiation to people with lung cancer. Normally, the radiation plan is made before treatment starts, but tumors can shrink during treatment, which may expose healthy tissue to unnecessary radiation. In this study, the radiation plan is update…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…

This study tests a conversation aid that helps lung cancer patients and their doctors make treatment decisions together. About 100 patients with advanced non-small cell lung cancer will use the tool during appointments to see if it improves shared decision-making and satisfaction…

This study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…

This study looks at whether giving early-stage lung cancer patients information about quality of life helps them choose between surgery and radiation therapy. About 150 adults with stage I-II lung cancer who can have either treatment will take part. The goal is to see if this inf…