SOLID CARCINOMA

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant) along with the immunotherapy drug nivolumab can shrink tumors in people with advanced solid cancers that stopped responding to prior immunotherapy. About 50 adults with advanced, unresectabl…

This early-stage study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, or related mutations). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. …

This early-stage trial tests an experimental drug, DM005, in about 136 people with advanced solid tumors like lung, head and neck, or other cancers that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see how the b…

This study is for adults with advanced solid tumors that have stopped responding to standard treatments. It tests an experimental drug called INV-1120, given alone or together with the immunotherapy pembrolizumab. The main goals are to find the safest dose and to watch for side e…

This early-stage study is testing a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose and check for side effects. The study is…

This early-phase study tests a new drug called DM002 in about 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; second, giv…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study looks at how gut bacteria affect cancer immunotherapy in people with advanced solid tumors. It has two parts: first, identifying bacterial markers linked to treatment response; second, testing whether fecal transplants from healthy donors can make immunotherapy work be…

This study looks at whether a simple blood test can predict blood clots in people with certain cancers (lung, pancreas, stomach, or brain). Clots are a major risk for cancer patients and can be life-threatening. Researchers will track 200 patients for 12 months to see if changes …