SICKLE CELL DISEASE
Clinical trials for SICKLE CELL DISEASE explained in plain language.
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Tracking sickle cell patients on new medication for 5 years
Disease control TerminatedThis study followed 265 people with sickle cell disease who were already taking Oxbryta, a medication approved to help manage the condition. Researchers collected real-world data over 5 years to understand how the drug affects patients' blood markers, complications, and quality o…
Matched conditions: SICKLE CELL DISEASE
Sponsor: Pfizer • Aim: Disease control
Last updated Apr 02, 2026 14:57 UTC
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Scientists test CRISPR gene editing to fight sickle cell pain
Disease control TerminatedThis early-stage study tested a new gene-editing treatment for people with severe sickle cell disease. Doctors collected patients' own blood stem cells, used CRISPR technology to edit a gene to boost protective fetal hemoglobin, and then transplanted the cells back after chemothe…
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Sickle cell patients get extended access to promising drug in safety study
Disease control TerminatedThis study aimed to check the long-term safety of the drug voxelotor for people with sickle cell disease. It was open to patients who had already taken part in earlier voxelotor trials. The main goal was to monitor for side effects and sickle cell complications over a longer peri…
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE3 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Pfizer tests Long-Term safety of promising sickle cell treatment
Disease control TerminatedThis study aimed to check the long-term safety of the experimental drug GBT021601 for people with sickle cell disease. It enrolled 47 participants who had already taken the drug in earlier trials, allowing them to continue treatment while researchers monitored for side effects ov…
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE2, PHASE3 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Sickle cell patients get extended access to promising drug in safety Follow-Up
Disease control TerminatedThis study allowed patients with sickle cell disease who had already completed a previous clinical trial of the drug voxelotor to continue taking it long-term. Researchers monitored 179 participants to understand the drug's safety over extended use and whether it continued to hel…
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE3 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Cancer drug tested to tame sickle Cell's agony
Disease control TerminatedThis small, early-stage study tested whether imatinib, a drug used for certain cancers, could help control sickle cell disease. It aimed to see if taking the pill daily for six months would reduce the frequency of severe pain episodes and other complications in young adults. The …
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Indiana University • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Sickle cell patients continue experimental drug to monitor Long-Term safety
Disease control TerminatedThis study aimed to check the long-term safety of inclacumab, an experimental drug for sickle cell disease. It was for people who had already received the drug in a previous Pfizer trial. Participants received the drug every 12 weeks, and researchers tracked any side effects and …
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE3 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC
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Drug trial aims to protect Kids' brains from sickle cell damage
Disease control TerminatedThis study tested whether a medication called voxelotor could help protect children with sickle cell disease from strokes. It involved about 224 children, aged 2 to 15, who were at risk for stroke due to abnormal blood flow in their brains. Researchers compared the drug to a plac…
Matched conditions: SICKLE CELL DISEASE
Phase: PHASE3 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 18, 2026 14:40 UTC