SCHIZOPHRENIA DISORDERS

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either the drug or a placebo for 16 weeks, and researchers will track thei…

This early-stage study is testing a single dose of a long-acting injectable form of the drug brexpiprazole in healthy volunteers and people with schizophrenia. The main goal is to see if the injection is safe and tolerable, and how the body processes the drug. The study involves …

This study tests whether learning music—rhythm, singing, and body movement—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based cognitive training works better than standard c…

This study tests whether adding EMDR therapy to standard care helps reduce trauma symptoms in people with schizophrenia. About 187 participants will receive up to 26 sessions of EMDR and be followed for 6 months. The goal is to see if this approach can improve both trauma and psy…

This study looks at whether diroximel fumarate, a drug already used for multiple sclerosis, can increase glutathione—a key antioxidant—in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the drug …

This study looks at how the brain's earliest visual processing areas work in people with schizophrenia, bipolar disorder, or schizoaffective disorder. Researchers will use EEG (a non-invasive brain wave test) to measure electrical activity while participants view simple visual pa…

This study looks at whether practicing a mock musical instrument can improve the brain's white matter—the wiring that helps different regions communicate quickly—in people with schizophrenia. Researchers will enroll 36 participants aged 15–45 with schizophrenia or related disorde…

This study will closely examine the physical and mental health of 100 adults admitted to NHS psychiatric wards. Researchers want to learn how common physical illnesses are in this group and how severe their mental health symptoms are. The goal is to better understand the overall …

This study looks at how people with schizophrenia learn and update their beliefs, and whether treating persecutory delusions changes that process. About 120 adults will receive either cognitive behavioral therapy or standard care plus check-ins for 16 weeks. Researchers will use …

This study is testing a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants accurately judge their own skills. Researchers want to see if this approach i…

This study will collect genetic samples and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns that could lead to b…

This study uses a non-invasive brain stimulation technique called TMS to explore how the hippocampus works in people with schizophrenia. Researchers aim to understand if they can safely change brain activity in this area, which may lead to better treatments. The study involves 60…