Schizophrenia disorder

This study follows 250 Chinese adults with schizophrenia who are prescribed KarXT, a combination of xanomeline and trospium chloride. Over 17 weeks, researchers observe how doctors use the drug, how well patients stick with it, and what side effects occur. The goal is to see if K…

This trial tests whether adding semaglutide—a medication used for diabetes and weight management—to standard antipsychotic treatment can lower the 10-year risk of heart attack and stroke in people with schizophrenia who also have metabolic syndrome. The study will measure changes…

This study tests a brain implant called deep brain stimulation (DBS) to help six adults with severe aggression that hasn't improved with medication or other therapies. Participants have either autism or schizophrenia and live in locked psychiatric units. The implant targets a bra…

This early study tests a new drug called SIPI6398 in 9 people (healthy volunteers and schizophrenia patients). Researchers use brain scans to see how much of the drug reaches brain receptors linked to schizophrenia. The goal is to find the right dose and check safety, not yet to …

This study looks at whether an online education and support program can help people with schizophrenia or bipolar disorder stick to their medication plans. Researchers will compare digital questionnaires with pharmacy records to measure adherence. About 1,640 adults in Spain will…

This trial tests whether a brain-training method called decoded neurofeedback, done during MRI scans, can help people with schizophrenia or schizoaffective disorder reduce persistent auditory hallucinations—like hearing voices. Participants are randomly assigned to either the act…

This study compares two types of brain stimulation—accelerated theta burst and high-frequency TMS—against a sham (fake) treatment to see if they can improve cognitive problems like memory and attention in people with treatment-resistant schizophrenia. Ninety adults on clozapine w…

This study tests whether a daily supplement of sulforaphane, a compound found in broccoli sprouts, can improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. Sixty participants aged 12 to 45 who are stable on antipsychotic medicati…

This study tests whether an AI-powered app that guides chewing exercises can improve oral hygiene, chewing, and swallowing in people with schizophrenia. 100 participants from two hospitals will be randomly assigned to use the app before meals or receive standard care. The goal is…

This study will test whether educational sessions can improve health literacy and attitudes toward medication in 34 adults hospitalized with schizophrenia or related disorders. Participants will receive pamphlets and watch videos about their condition, then complete questionnaire…

This study tests whether a short virtual reality experience can reduce stigma toward people with schizophrenia among healthcare workers and students. Participants will watch two VR videos that simulate hallucinations and paranoid thoughts, then researchers measure changes in atti…