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Could a broccoli compound help schizophrenia symptoms?

NCT ID NCT07652866

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily supplement of sulforaphane, a compound found in broccoli sprouts, can improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. Sixty participants aged 12 to 45 who are stable on antipsychotic medication will receive either sulforaphane or a placebo for 12 weeks, followed by an optional 12-week open-label phase. The study will measure changes in symptom scales and brain imaging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sulforaphane (a compound found in broccoli sprouts)
What this could lead to
If it works, this could point toward a new way to help with hard-to-treat symptoms like lack of motivation and trouble thinking clearly in schizophrenia.
What could go wrong
This is a small, early-stage trial with only 60 people. The supplement may not work better than a placebo, and results may not apply to everyone with schizophrenia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of schizophrenia according to DSM-5 criteria. 2. First-episode or illness duration ≤ 10 years, but currently in a non-acute phase of schizophrenia. 3. Negative symptoms present for ≥ 6 months prior to study entry. Patients must be outpatients or hospitalized for social reasons rather than symptom exacerbation. 4. PANSS negative subscale (7 items) total score ≥ 20; at least one negative item score \> 3; no change \> 3 points between screening and baseline. PANSS positive subscale items related to agitation (P4 excitement, P6 suspiciousness/persecution, P7 hostility, G8 uncooperativeness, G14 poor impulse control) each ≤ 4. 5. Currently taking ≤ 2 antipsychotic medications. 6. Antipsychotic regimen remains unchanged during the study period. 7. No anticipated relocation, transportation difficulties, or access problems that would interfere with study participation. 8. Able to understand and comply with study procedures, complete all required tests and examinations, communicate well with the investigator, and voluntarily provide written informed consent Exclusion Criteria: 1. Psychiatric symptoms attributable to any other DSM-5 diagnosis besides schizophrenia. 2. History of substance dependence, or psychotic symptoms caused by other medical conditions. 3. Calgary Depression Scale for Schizophrenia (CDSS) total score \> 6. 4. Barnes Akathisia Rating Scale (BARS) score indicating at least moderate akathisia. 5. Current or past major physical illness, neurological disorder, or traumatic brain injury affecting brain structure/function. 6. Suicidal attempt or current suicidal ideation. 7. Currently receiving antidepressants, mood stabilizers; or use of rTMS, MECT, or systematic psychotherapy within 3 months or for the current episode. 8. Current use of medications that may affect cognitive function, such as Ginkgo biloba extract, minocycline, selegiline. 9. Presence of hepatic or renal insufficiency, severe gastrointestinal, respiratory, endocrine, or hematologic disorders, or disorders of absorption or metabolism. 10. Pregnant or breastfeeding women.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Xiangya Second Hospital

    Changsha, China, 410001, China

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