SARCOMA,SOFT TISSUE

This study tests whether giving a targeted drug (anlotinib) along with radiation therapy before surgery can safely reduce major wound complications in adults with soft tissue sarcoma of the arms, legs, or trunk. About 30 participants will receive the combination treatment, and re…

This study tests a new approach for people with high-risk soft tissue sarcoma in the arms, legs, or trunk. The treatment combines chemotherapy, targeted heat therapy (hyperthermia), radiation, and surgery before any other treatment. The goal is to see if this total neoadjuvant tr…

This study tests a chemotherapy combination (pemetrexed and cisplatin) in people with advanced or recurrent soft tissue sarcoma that has not responded well to previous treatments. The goal is to see if this drug pair can slow or stop tumor growth. About 164 adults with specific s…

This study is for people with soft tissue sarcoma who need radiation before surgery. It compares a standard 14-session radiation schedule with a shorter 5-session schedule to see if the shorter course causes fewer wound complications after surgery while still controlling the tumo…

This study tests whether a single-use negative pressure wound dressing (PICO 14) can reduce wound complications after surgery for soft tissue sarcoma in the arms or legs. The trial involves 48 adults who have had radiation therapy before surgery. Participants are randomly assigne…

This study tests a new treatment for people with advanced cancers that have spread and express a protein called NY-ESO-1. Patients receive a single infusion of their own immune cells that have been genetically modified to recognize and attack cancer cells. The goal is to see if t…

This study tests a faster, stronger type of radiation (using protons or carbon ions) given before surgery for a rare cancer called retroperitoneal sarcoma. The goal is to see if this approach is safe and practical by tracking side effects and whether patients can complete the pla…

This study tests whether adding the diabetes drug metformin to standard cancer therapy helps people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will receive metformin alongside their first-line treatment. The main go…

This study tests whether adding an experimental immune-boosting drug (retifanlimab) to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this rare cancer will recei…

This study looks at how serious walking problems are for children with bone or soft tissue cancer who have had leg surgery. Researchers will use 3D cameras and sensors to track their movement for up to 5 years. Healthy children of the same age will also take part to compare resul…

This study is creating a worldwide database to track people diagnosed with epithelioid hemangioendothelioma (EHE), a very rare type of cancer that grows in blood vessels. Researchers will collect information from 100 adult patients across Europe and the UK to learn how the diseas…

This study looks at different surgical methods used to remove retroperitoneal sarcomas when part of the colon or rectum must also be removed. Researchers will track complications and how patients' quality of life changes after surgery. The goal is to help surgeons make better dec…

This study is a registry that will collect information from up to 9,000 people in Germany with sarcoma or carcinosarcoma. Researchers will track what treatments patients receive and how they do over time. The goal is to better understand these rare cancers, not to test a new trea…