SAFETY

This early-stage clinical trial is testing a new drug called HY07121 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose, understand how the body processes the drug, and see if it shows any early signs o…

This early-stage trial is testing the safety of injecting lab-grown nerve cells into the spinal fluid of people with recent spinal cord injuries. The study will enroll 12 adults who were injured 2 to 8 weeks ago to see if the treatment is safe and if it might help improve movemen…

This study is testing a new combination of drugs for people with advanced colorectal cancer that has spread and worsened after their first treatment. The goal is to see if adding an immunotherapy drug (AK104) to standard chemotherapy and targeted therapy can shrink tumors and con…

This early-stage study is testing the safety of a new medication called GenSci098 for people with Graves' disease, an autoimmune condition that causes overactive thyroid. Researchers will give 24 participants increasing doses of the drug to check for side effects and see how the …

This early-stage study is testing whether stem cells taken from amniotic fluid can help heal the extremely painful and dangerous skin wounds caused by calciphylaxis, a rare complication of kidney disease. Nine adult patients with calciphylaxis will receive the stem cell treatment…

This early-stage study aims to test the safety and side effects of a new injectable drug called GenSci098 in people with thyroid eye disease. Researchers will give increasing doses to 76 participants to see how their bodies handle the medication and monitor for any problems. The …

This study is testing a new drug, HYP-2090PTSA, for people with advanced solid tumors that have a specific genetic change called a KRAS mutation. The first part aims to find a safe and effective dose. The second part will explore how well the drug works for certain cancers with a…

This study is testing if taking a turmeric supplement (curcumin) for two weeks can help detect Alzheimer's disease. Researchers want to see if curcumin travels to the eye and sticks to specific protein deposits linked to Alzheimer's, making them visible. They will also check the …

This early-stage study is testing whether psilocybin (the active compound in 'magic mushrooms'), combined with therapy, can safely help reduce severe emotional distress in people with advanced cancer. Fifteen participants will receive therapy sessions and one dose of psilocybin t…

This study aims to find out if a new oral medication called IRL757 is safe and tolerable for people with Parkinson's disease who also experience apathy—a lack of interest or motivation. About 75 participants will take either the study drug or a placebo (inactive pill) daily for 1…

This is an early safety study for a new combination antibiotic pill. Researchers will give the drug to about 46 healthy adults to see how safe it is and to measure how the body absorbs and processes it. The main goal is to understand the drug's behavior in the body and identify a…

This is the first study in humans to test a new inhaled compound called RCS-21. The main goal is to check if it is safe and how the body processes it. Healthy volunteers will inhale a single dose and be closely monitored for side effects. This is an early, basic safety study, not…

This study aims to check the long-term safety of a dietary supplement called palmitoylethanolamide (PEA) in healthy adults. Over 200 participants will take either the supplement or a placebo daily for 12 months, with researchers closely monitoring their health for any side effect…

This study aims to monitor the safety of the Prevenar 20 pneumococcal vaccine in routine medical practice in Korea. It will enroll 660 participants aged 6 weeks and older who receive the vaccine as part of their normal healthcare. Researchers will track any side effects or reacti…

This study is creating a registry to observe the safety and success of a newer technique for accessing arteries in the wrist during heart procedures. It will enroll 3,600 adults who need a heart scan or intervention and have a suitable artery. The goal is to gather real-world dat…

This study is a global survey asking doctors, nurses, and respiratory therapists about their experiences using non-invasive ventilation (NIV) - a mask-based breathing support system - outside intensive care units. Researchers want to understand current practices, identify safety …