RETINAL DISEASE

This study tests an experimental drug called sepofarsen in people with a rare genetic eye disease (LCA10) that causes severe vision loss from childhood. The drug is injected into one eye, while the other eye gets a placebo, to see if it can improve vision safely. About 32 partici…

This study tests a drug called ultevursen in 81 people with retinitis pigmentosa caused by a specific gene change (USH2A). The drug is injected into the eye and compared to a sham injection. The goal is to see if it can slow the loss of vision over two years. Participants must be…

This study tests an investigational drug called VP-001, given as an eye injection, for people with a rare genetic form of retinitis pigmentosa caused by PRPF31 mutations. The goal is to see if it is safe and can help slow vision loss. The trial involves 16 adults who have already…

This study tests a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients will …

This study looks at blood flow in the back of the eye in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare eye scans from 60 participants — half with PXE and half healthy — to see if early changes in blood flow…

This study collects skin, hair, blood, saliva, or urine samples from people with certain eye diseases (like macular degeneration) and healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new drugs…

This study tests two different eye-imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. About 30 participants, including healthy adults and children with eye conditions, will be scanned. The goal is to find a device that gives doctors …

This study follows 100 adults with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Over two years, researchers will use advanced eye scans to track tiny changes in blood vessels and retinal layers. The goal is to find earl…

This study tests a digital platform called the Genetics Navigator, designed to help patients and parents of children who are offered genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults will participate, …

This registry collects health information from people with inherited retinal diseases to help researchers better understand these conditions. Participants create an online profile and can update it over time. The goal is to speed up research and connect people with clinical trial…

This study is gathering detailed eye scans from 180 people, including those with healthy eyes and those with retinal disease, glaucoma, or corneal conditions. The goal is to collect data that may help researchers better understand these eye diseases. Participants will have their …

This study tests a new imaging tool that gives surgeons a live, 3D view inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or diabetic retinopathy, as well as healthy volunteers. The goal is to see if this t…

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to create a research database to help scientists understand why some people get eye diseases and oth…

This study compares two newer ultrawide field cameras (Clarus and Optos) to the standard imaging system for taking pictures of the back of the eye in people with inherited retinal diseases. The goal is to see if these newer cameras provide the same quality of information for moni…

This study looks at whether certain genes make some people more likely to get eye damage from the drug Plaquenil, used for autoimmune diseases like lupus. Researchers will compare people who have had eye damage with those who haven't, using blood tests and eye exams. No treatment…