RETINAL DISEASE

This study is testing whether an experimental drug called ultevursen, given as an injection into the eye, can slow the progression of vision loss in people with retinitis pigmentosa caused by specific mutations in the USH2A gene. The trial will enroll 81 participants, who will be…

This study is testing whether regular eye injections of an experimental drug called sepofarsen can improve vision in people with a specific genetic form of Leber congenital amaurosis (LCA), which causes severe vision loss from childhood. In this carefully designed trial, each par…

This study is testing the safety and effectiveness of repeat injections of an experimental drug, VP-001, into the eye. It is for adults with a rare, inherited form of vision loss called PRPF31 mutation-associated retinal dystrophy. The goal is to see if the injections can help co…

This study is testing a new 3D imaging system that gives eye surgeons a better view during operations. The technology provides real-time, detailed images of the eye's internal structures while surgery is happening. Researchers want to see if this helps surgeons perform more preci…

This study is testing a new, easier-to-use version of a handheld eye scanner. The goal is to see if its automatic alignment feature can take clear pictures of the back of the eye (retina) in both adults and children. Researchers will enroll 50 volunteers and patients to see how w…

This study aims to compare two types of handheld eye scanners to see which works better for imaging children's retinas. Researchers will test both a contact scanner and a non-contact scanner on 20 pediatric patients and 10 healthy adults. The goal is to determine which system pro…

This study aims to understand a rare, inherited disease called pseudoxanthoma elasticum (PXE) by looking at the eyes. Researchers will use a non-invasive eye scan to compare blood flow in the back of the eye between 60 healthy volunteers and 60 people with PXE. The goal is to fin…

This study aims to build a large database of health information and physical samples (like blood and tissue) from people with and without various retinal diseases. Researchers will collect this data to help future studies understand why eye diseases develop and how people respond…

This study aims to understand how diabetic eye disease (retinopathy) gets worse over time. Researchers will use advanced, non-invasive eye scans to closely monitor 100 patients with moderate to severe diabetic retinopathy for two years. The goal is to identify early warning signs…

This study aims to understand why some people develop serious eye damage from Plaquenil (hydroxychloroquine), a drug used for lupus and arthritis, while most do not. Researchers will compare the genes of people who have experienced this eye damage with those who have taken the dr…

This study aims to collect detailed scan images of the eye from 180 people. It includes participants with various eye conditions like macular degeneration, glaucoma, and corneal diseases, as well as people with healthy eyes. The goal is to build a large database of images to help…

This study is testing a new digital platform called the Genetics Navigator. It's designed to help guide patients and parents through the complex process of genetic testing for conditions like cancer, heart disease, and epilepsy. Researchers want to see if using this online tool r…

This study aims to understand and eventually find treatments for serious eye diseases that can lead to blindness, like macular degeneration. Researchers will collect simple samples like hair, skin, or blood from people with these conditions and from healthy volunteers. In the lab…

This study aims to compare two newer, wide-angle eye cameras to the current standard camera to see if they provide the same quality of information for monitoring inherited retinal diseases. Researchers will take pictures of the back of the eye using all three cameras in about 50 …