RETINAL DISEASE

This study tests a drug called ultevursen in people with retinitis pigmentosa caused by changes in a specific part of the USH2A gene. The drug is injected into the eye and is designed to slow the loss of vision over two years. The trial includes 81 adults and children aged 8 and …

This study tests two doses of an eye injection called VP-001 in 16 adults with a rare inherited eye disease (PRPF31 mutation) that causes vision loss. The goal is to see if repeated doses are safe and can help slow the disease. Participants must have been in a prior VP-001 study …

This study tests an investigational drug called sepofarsen in people with Leber congenital amaurosis (LCA), a rare genetic eye disease that causes severe vision loss from birth. The trial includes 32 participants aged 6 and older who have a specific mutation in the CEP290 gene. E…

This study is testing a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients …

This study compares two new ultrawide field cameras (Clarus and Optos) to the standard imaging system for people with inherited retinal diseases. Researchers want to see if the newer cameras can capture the same detailed images of the back of the eye. Participants will have their…

This study tests two different eye imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. Researchers will compare a new contact device with a noncontact device in 30 participants, including healthy adults and children. The goal is to fi…

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new …

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, used for autoimmune diseases like lupus. Researchers will compare people who have had eye damage with those who haven't, using blood tests and eye exams. No treat…

This study tests a new microscope that shows live 3D images inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or macular holes, as well as healthy volunteers. The goal is to see if this technology helps sur…

This study collects blood, tissue, and health information from 650 people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to build a database and biobank for future research, not to provide treatment. Participants will…

This study looks at blood flow in the back of the eye in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare eye scans from 60 participants — half with PXE and half healthy — to see if changes in blood flow can s…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Researchers will use advanced eye scans and tests over two years to track small changes in the retina. The goal is to find early warning si…

This study gathers detailed eye scans from 180 adults with healthy eyes or conditions like retinal disease, glaucoma, or corneal disease. The goal is to collect data that may help doctors better understand and diagnose these conditions in the future. Participants will have their …

This study tests a digital platform called the Genetics Navigator that helps patients and parents of children get genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults referred for genetic testing at two h…