RENAL CELL CANCER

This study tests a new cancer vaccine called Modi-1 in 168 people with advanced breast, head & neck, ovarian, or kidney cancer. The vaccine is designed to help the immune system recognize and attack cancer cells. Some participants will receive the vaccine alone, while others will…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. The goal is to see what doses work best and how often side effects cause treatment breaks. About 50 participants will be followed for a year to tr…

This study tests a new treatment for several types of cancer that have a specific marker called CD70. Researchers take a patient's own white blood cells, modify their genes in the lab to help them recognize and attack CD70-positive cancer cells, and then return them to the patien…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This study tests the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side ef…

This study tests whether special ultrasound scans can predict how well the kidneys will work after surgery for kidney cancer. About 285 adults who are having part or all of a kidney removed will get these scans before and after surgery. Researchers will compare the scan results w…