Pulmonary tuberculosis

This Phase 3 trial tests the GamTBvac vaccine to prevent active pulmonary tuberculosis in adults aged 18 and older. The study includes people with and without a prior history of TB, comparing the vaccine to a placebo. Researchers will monitor how many participants develop active …

This study tests a digital package called CARE-TB to help people with tuberculosis take their medication as prescribed. The package includes video observation of pill-taking, digital reminders, telecounselling, and educational materials. Researchers will compare this approach to …

This Phase 2 trial tests whether a new drug called TBAJ-876, or the existing drug bedaquiline, combined with pretomanid and linezolid, can treat drug-sensitive tuberculosis faster and more effectively than the standard 6-month regimen. About 309 adults with newly diagnosed TB are…

This study tests a package of community support, family help, digital reminders, and healthcare worker training to improve how tuberculosis is found and treated in South Ethiopia. About 278 patients, family members, and health workers will take part. The goal is to see if this co…

This study tests a smartphone app and a tablet dashboard for community health workers to support people with both tuberculosis (TB) and HIV in South Africa. The app helps patients stay on track with their medications, while the dashboard alerts health workers if someone needs ext…

This study tests I-FALMIN, a supplement made from toman fish, in 112 adults with pulmonary tuberculosis and low albumin levels. Participants take the supplement or a placebo for one day alongside standard TB treatment. Researchers will check if albumin levels and body mass index …

This phase 3 trial is testing a 6-month, all-oral combination of four drugs (bedaquiline, delamanid, linezolid, and levofloxacin or clofazimine) to treat rifampin-resistant tuberculosis in Chinese teenagers and adults aged 12 and older. The goal is to see if this shorter regimen …

Researchers are studying whether two tests, one on sputum and one on urine, can accurately detect tuberculosis in people suspected of having the infection. The trial enrolls 150 patients at tertiary care hospitals who can provide both sputum and urine samples. The goal is to see …

This study evaluates a new PCR test (Bioneer Q-RFIA kit) for quickly and accurately detecting tuberculosis (TB) and resistance to key antibiotics. About 2,350 adults with TB symptoms will provide samples to see how well the test works compared to standard methods. The goal is to …

Researchers in Zambia are tracking 374 adults with pulmonary tuberculosis to compare treatment outcomes between those with and without HIV. The study follows participants through the end of TB treatment to see who achieves a successful outcome. The goal is to inform TB treatment …

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study investigates whether a blood test can detect the bacteria that cause tuberculosis (TB) in people with active TB and their asymptomatic household contacts. Researchers in Uganda will use several methods, including a DNA-based test, to look for TB bacteria in blood sampl…

This study in India will test a low-cost urine check (IsoScreen) on 900 adults being treated for tuberculosis. The test detects whether they have taken their medication recently. Researchers want to see if the test can reliably find people who are missing doses, so that doctors c…