Procedural pain

Preterm newborns in intensive care often need repeated heel pricks for blood tests, which can cause pain and stress. This trial tests whether giving a soft crochet octopus to hold during the procedure reduces pain and improves behavioral responses. Researchers will compare preter…

This trial tests whether virtual reality (VR) distraction can reduce pain, anxiety, and the need for pain medications during prone pain procedures, compared to standard care alone. About 230 adults undergoing such procedures at a pain clinic will be randomly assigned to either us…

This study tests two simple, non-drug methods to reduce pain during routine vaccination in 12-month-old infants. One group gets a cold spray on the injection site before the shot, another gets a gentle tapping technique near the site during the injection, and a third gets standar…

This study tests whether a gentle electrical current applied to specific points on the skin (called TEAS) can reduce side effects like low oxygen or blood pressure during a procedure to treat bile duct problems (ERCP). About 130 adults will be randomly assigned to receive either …

This study tests two simple, non-drug methods to help women feel less anxious and in pain during mammograms and breast ultrasounds. One group will squeeze a stress ball before and during the procedure, another will receive calming words and gentle touch, and a third will get stan…

This study compares a needle-free injection system to a traditional dental syringe for numbing children's teeth before extraction. About 60 healthy kids aged 6 to 12 will be randomly assigned to one method. Researchers will measure their anxiety, pain, and vital signs to see if t…

Propofol, a common anesthesia drug, often causes pain when injected. This trial will compare two drugs—nalbuphine and lidocaine—given before propofol to see which reduces that pain better. 92 adults having elective surgery will take part, and their pain will be measured on a simp…

This study tests whether a handheld palm stimulator can reduce pain, fear, and anxiety when cancer patients get an IV for chemotherapy. About 90 adults will be randomly assigned to either squeeze the device during the procedure or receive standard care. The goal is to provide a l…

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…