PRE-DIABETES

This study compares two healthy diets—one centered on beef and one following a typical US pattern—to see which better lowers inflammation and improves other health markers in people with metabolic syndrome or pre-diabetes. About 56 adults aged 18-74 with elevated inflammation and…

This study looks at how fat cells work in people with normal-weight type 2 diabetes compared to those with overweight diabetes or no diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adult…

This study looks at whether time-restricted eating (eating only during a set number of hours each day) can improve health in people with metabolic syndrome or pre-diabetes. About 140 adults will either follow their usual diet or limit eating to a specific time window. Researchers…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study tests whether having a stable daily routine—like consistent meal times and sleep—can improve blood sugar control and reduce body fat in people with pre-diabetes. Researchers will track 34 adults using activity monitors and MRI scans. The goal is to see if this simple, …

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests whether two approved drugs, mirabegron and tadalafil, can improve how the body handles sugar in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drugs can reverse prediabetes a…

This study aims to identify children and adults (ages 1-45) who are at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Participants must have a family member or close friend diagnosed with type 1 diabetes before age…

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will do both tests to see if the home version is accurate and practical. The goal is to make…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people who have trouble digesting lactose (lactose intolerance) and have pre-diabetes. Researchers want to see if milk changes gut bacteria in a way that helps control blood sugar. About 40…

This study tests whether adding reminders to electronic medical records helps doctors provide better care for people with pre-diabetes. About 6000 adults aged 21-59 with pre-diabetes will take part. Some clinics will use the reminders; others will not. The goal is to see if the r…

This study looks at whether using a sit-stand desk can help prevent type 2 diabetes in people who are overweight and sit a lot at work. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to a con…

This study tests low-cost treatments to help Hispanic adults with prediabetes and obesity bring blood sugar back to normal, lose weight, and lower heart disease risk. Researchers will measure changes in blood sugar, body fat, and heart function. The goal is to find affordable str…

This study aims to understand blood sugar patterns in people with and without prediabetes using a continuous glucose monitor. Researchers will collect data from 2,000 adults to identify differences that could help detect or manage prediabetes earlier. Participants wear a small se…

This study tests whether wearing a continuous glucose monitor (CGM) helps adults with prediabetes improve their diet, physical activity, and weight compared to standard health coaching. About 76 participants will be randomly assigned to receive either a CGM plus coaching or coach…

This study looks at why people with pre-diabetes or type 2 diabetes feel more tired and weak in their legs during exercise. Researchers think it may be due to blood vessel problems. They will test a special exercise program that uses blood flow restriction to better understand th…