Post-traumatic stress disorder (PTSD)

This study asks whether tapering and stopping certain psychotropic medications before intensive trauma-focused psychotherapy helps people with PTSD more than continuing those medications during therapy. Researchers will compare patients treated under a new medication-review polic…

This trial tests whether transcranial magnetic stimulation (TMS) can engage the amygdala—the brain's fear center—in adults with post-traumatic stress disorder (PTSD). Participants receive either active or sham TMS every weekday for six weeks, guided by MRI to target a personalize…

This trial tests whether propranolol, a blood pressure drug, can reduce PTSD symptoms in women who have experienced severe violence. Participants take propranolol and then revisit their traumatic memories in a structured session with a psychologist. The study compares this approa…

This trial tests whether combining eye movements with different ways of reactivating a memory can reduce the frequency and distress of intrusive trauma memories in people with PTSD. Participants are randomly assigned to one of three procedures: unconscious trauma reactivation, ac…

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

People hospitalized after a traumatic injury often face post-traumatic stress, depression, and substance use problems. This study tests a program called Trauma Resilience and Recovery Program Portal 2.0, which adds bedside screening, education, text-message check-ins, and follow-…

Researchers are testing whether brexanolone, an intravenous drug approved for postpartum depression, can reduce PTSD symptoms and stress-related drinking in veterans who have both PTSD and alcohol use disorder. The study enrolls 40 veterans aged 21 to 70. Participants receive one…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This phase 3 trial tests whether a slow-release form of melatonin can improve sleep in 120 children and adolescents (ages 2-17.5) with PTSD who have significant sleep disturbances. Participants will receive either melatonin or a placebo for 13 weeks. The study aims to see if mela…

This study tests a one-week course of brain stimulation (called iTBS) for veterans who have both PTSD and chronic pain. Thirty veterans will receive 5-6 short sessions each day for five days, with no placebo group. Researchers will track changes in PTSD symptoms, pain, mood, and …

This study tests a therapy called CFTSI for children aged 7 to 17 who have experienced a traumatic event in the last 3 months. The goal is to see if CFTSI reduces post-traumatic stress symptoms better than standard supportive therapy. 140 children and their families will take par…

This study asks whether routine medical data can predict which survivors of an emergency intensive care unit (EICU) stay will develop post-traumatic stress disorder (PTSD) one month after leaving the hospital. Researchers will follow about 800 adult patients, collecting details f…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…