PLASMA CELL LEUKEMIA

This study tests a new treatment plan for people newly diagnosed with primary plasma cell leukemia, a rare and aggressive blood cancer. The approach combines standard chemotherapy drugs with two rounds of CAR T-cell therapy and a stem cell transplant. The goal is to see if this i…

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, or multiple myeloma that have come back or not responded to standard therapy. Participants receive chemotherapy followed by specially engineered natural killer (NK) cells from a donor, designe…

This study tests a 'go-slow' treatment for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, patients begin with just two medications and add a third after two months. The goal is to see if this gentle approach helps patients stick…

This study tests whether a drug called budesonide can prevent severe diarrhea in people with multiple myeloma who are getting a stem cell transplant. About 120 adults will be randomly assigned to receive either budesonide or a placebo alongside standard care. The goal is to see i…

This study collects and stores blood and tissue samples from 6,000 people with multiple myeloma or related plasma cell disorders. Researchers will use these samples to better understand the diseases and improve treatments. Participants provide samples at regular visits but receiv…

This study builds a registry of 2000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants complete health assessments and may give a blood sample to study aging markers. The goal is to gather data that will support future research, not to test…