PLASMA CELL LEUKEMIA

This study tests whether giving specially engineered natural killer (NK) cells from donated cord blood, along with chemotherapy, is safe and effective for people with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and multiple myeloma. About 80 participants will…

This study tests a 'go-slow' treatment plan for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, patients first receive two medications (isatuximab and dexamethasone) and then slowly add a third (lenalidomide) after two months. Th…

This study tests a treatment plan for people newly diagnosed with primary plasma cell leukemia, a rare and aggressive blood cancer. The approach combines standard chemotherapy drugs (bortezomib, lenalidomide, dexamethasone) with two rounds of CAR T-cell therapy and a stem cell tr…

This study tests whether a medication called budesonide can prevent severe diarrhea in people with multiple myeloma who are receiving a stem cell transplant. About 120 adults will be randomly assigned to get either budesonide or a placebo alongside standard care. The goal is to s…

This study creates a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will track frailty, muscle loss, and other age-related health issues using surveys and physical tests. The goal is to better understand this group's …

This study is building a registry of up to 2,000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants complete health assessments and may give a blood sample to study aging markers. The goal is to gather information to support future research,…

This study collects and stores blood and tissue samples from 6,000 people with multiple myeloma, smoldering myeloma, plasma cell leukemia, or MGUS. Researchers will use these samples to better understand these diseases and improve future treatments. Participants provide samples a…