PERIPHERAL NEUROPATHY

This study tests whether special smart insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. The insoles measure pressure and temperature on the feet and alert the user to problem areas. 400 high-risk participants will be followed to see …

This study tests whether taking polyunsaturated fatty acids (like omega-3s) can prevent nerve damage in the hands and feet of people with colorectal cancer who receive oxaliplatin chemotherapy after surgery. About 120 participants will be followed for 8 months to see if the suppl…

This study tests if using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatment. Th…

This study tests whether Tai Chi, alpha-lipoic acid supplements, and acupuncture can help reduce nerve pain and tingling caused by chemotherapy in people with gastrointestinal cancer. About 60 adults who finished chemo at least three months ago will try these treatments over 16 w…

This study tests whether fenofibrate, a drug used for high cholesterol, can reduce nerve damage (peripheral neuropathy) caused by standard chemotherapy for multiple myeloma. About 44 newly diagnosed patients will receive either chemotherapy alone or chemotherapy plus fenofibrate.…

This study tests if a new type of magnetic stimulation (AtMS) can reduce nerve pain caused by injury or surgery. About 180 veterans and active-duty military with chronic nerve pain will receive either AtMS, a fixed magnetic stimulation, or a sham treatment over 16 weeks. Research…

This study tests Scrambler Therapy, a non-invasive device treatment, to reduce painful nerve damage caused by chemotherapy in adolescents and young adults (ages 15-39) who have finished active cancer treatment. Participants will be randomly assigned to receive the therapy either …

This study looks at whether turning a nerve stimulator on and off in short cycles can provide the same or better pain relief as continuous stimulation. About 30 adults who already have a spinal nerve stimulator and get at least 50% pain relief will try two different on/off patter…

This study aims to find out if the hormone amylin, which is higher in people with type 2 diabetes, is related to nerve damage (peripheral neuropathy). Researchers will collect blood and small skin samples from 40 participants and test their responses to heat, cold, and pressure. …

This study aims to improve how doctors observe nerves and muscles using ultrasound, a safe imaging technique. Researchers will collect normal measurements from healthy adults and compare them to people with neuromuscular disorders. Participants will have up to 5 clinic visits for…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study looks at how nerves change in people who develop nerve damage from the chemotherapy drug cisplatin. Researchers will use a special nerve test to measure these changes in 60 adults starting cisplatin treatment. The goal is to better understand the condition and find ear…

This study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will check participants once a year to see how the disease progresses. The goal is to learn more about the condition and find better ways to measure it in future studies.

This study aims to see if special force sensors can reliably measure how tight a carbon-fiber leg brace (ankle-foot orthosis) presses against the leg. Researchers will test 60 people: healthy volunteers, regular brace users without nerve damage, and regular brace users with perip…

This study looks at whether ultrasound can detect nerve changes in people with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Researchers will compare ultrasound images with standard nerve tests to see if ultrasound helps diagn…