PALB2 GENE MUTATION
Clinical trials for PALB2 GENE MUTATION explained in plain language.
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New combo pill aims to shrink tumors in patients with BRCA and related gene mutations
Disease control Recruiting nowThis early-phase study tests whether combining two oral drugs, olaparib and ASTX727, can safely shrink advanced solid tumors in adults with inherited or acquired mutations in BRCA1, BRCA2, PALB2, ATM, or CHEK2 genes. About 18 participants will receive the combination to find the …
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: Pamela Munster • Aim: Disease control
Last updated May 26, 2026 08:30 UTC
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Could a stem cell boost help fight hard-to-treat cancers?
Disease control Recruiting nowThis early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer that has spread. The treatment combines chemotherapy drugs with high-dose vitamin C and the patient's own stem cells to try to overcome drug resistance. The main goal is to ch…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: General Oncology, Inc. • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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New combo therapy targets Hard-to-Treat cancers
Disease control Recruiting nowThis early-stage trial tests a combination of two drugs, niraparib and irinotecan, in people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The main goal is to find a safe dose and understand side effects. About 24 adults with cancers…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 18, 2026 12:13 UTC
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New hope for pancreatic cancer: targeted combo trial for BRCA/PALB2 patients
Disease control Recruiting nowThis study tests a new combination of chemotherapy drugs (NABPLAGEM) against the standard combo for people with advanced pancreatic cancer that has a BRCA1/2 or PALB2 gene mutation. The goal is to see if the new combo works better at shrinking tumors and helping people live longe…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2, PHASE3 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New scan could spot hidden prostate cancer spread in men with gene mutations
Diagnosis Recruiting nowThis study aims to see if a type of PET-CT scan (FCH-PET-CT) is better than standard scans (bone scan and MRI/CT) at finding cancer that has spread outside the pelvis in men with prostate cancer who have specific gene mutations (like BRCA). About 50 men with these mutations will …
Matched conditions: PALB2 GENE MUTATION
Sponsor: Institute of Cancer Research, United Kingdom • Aim: Diagnosis
Last updated May 26, 2026 08:45 UTC
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Can digital tools and direct family outreach boost genetic testing uptake?
Knowledge-focused Recruiting nowThis study looks at two new approaches to cancer genetic counseling. The first part (EfFORT) tests whether having healthcare providers directly contact family members of people with harmful gene changes leads to more genetic testing, compared to the usual method of patients telli…
Matched conditions: PALB2 GENE MUTATION
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 08:30 UTC