PALB2 GENE MUTATION
Clinical trials for PALB2 GENE MUTATION explained in plain language.
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New hope: targeted drug olaparib shows promise for Hard-to-Treat breast cancer
Disease control OngoingThis study tests a drug called olaparib in people with metastatic breast cancer that has spread beyond the breast. Participants must have a specific genetic change in their tumor that may make it sensitive to this drug. The goal is to see if olaparib can shrink tumors or slow can…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Disease control
Last updated May 26, 2026 04:18 UTC
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New drug combo targets prostate cancer in understudied groups
Disease control TerminatedThis study was designed to test a combination of two drugs, niraparib and abiraterone plus prednisone, in Hispanic/Latino and Black patients with a specific type of metastatic prostate cancer that has certain gene mutations. The goal was to see if the treatment could lower PSA le…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: Qian Qin • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New hope for hard-to-treat cancers with BRCA gene changes
Disease control OngoingThis study tests a drug called talazoparib in 150 adults whose advanced cancer has stopped responding to standard treatments. The drug works by blocking an enzyme that helps tumor cells survive, and is given to people whose tumors have specific changes in BRCA or related genes. T…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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Genetic counseling by phone may ease cancer worry in High-Risk women
Knowledge-focused TerminatedThis study looks at whether watching an online genetics video, with or without phone counseling, can reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have at least one ovary. Resear…
Matched conditions: PALB2 GENE MUTATION
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 04:19 UTC
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New database aims to intercept deadly pancreatic cancer before it's too late
Knowledge-focused OngoingThis study is creating a secure database of 317 patients at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to find better ways to detect the disease early or even prevent it. No new treatments are being tested; i…
Matched conditions: PALB2 GENE MUTATION
Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Knowledge-focused
Last updated May 20, 2026 11:57 UTC