OUTPATIENT
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Higher antidepressant dose may raise risks for seniors with kidney disease
Knowledge-focused CompletedThis study looked at over 12,000 older adults (65+) with low kidney function to see if starting a higher dose (10 mg/day) of the antidepressant escitalopram is riskier than a lower dose (5 mg/day). The goal was to compare rates of hospitalization, emergency visits, or death withi…
Matched conditions: OUTPATIENT
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC
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Kidney patients warned: higher antidepressant dose may raise hospital risk
Knowledge-focused CompletedThis study analyzed health records of nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared those on a 50 mg daily dose to those on 25 mg to see if the higher dose led to more hospital visits, emergency dep…
Matched conditions: OUTPATIENT
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Knowledge-focused
Last updated May 20, 2026 11:56 UTC
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Higher antidepressant dose may be risky for seniors with kidney issues
Knowledge-focused CompletedThis study examined the safety of starting citalopram at 20 mg/day versus 10 mg/day in adults aged 65 and older with reduced kidney function. Researchers analyzed health records from over 7,000 participants to see if the higher dose increased the risk of hospitalization, emergenc…
Matched conditions: OUTPATIENT
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Knowledge-focused
Last updated May 18, 2026 12:02 UTC