OPTIC NEURITIS

This pilot study tests efgartigimod alfa (Vyvgart Hytrulo) against placebo in 20 adults having their first episode of moderate to severe optic neuritis, an inflammation of the optic nerve that can cause vision loss. Participants get two injections over a week, plus standard stero…

This study tests whether starting plasma exchange early, rather than waiting, leads to better vision in severe optic neuritis and less disability in severe transverse myelitis. About 382 adults with these inflammatory nerve conditions will be randomly assigned to early or rescue …

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This study tests a new drug called privosegtor in 210 adults with a first episode of optic neuritis, a condition that causes sudden vision loss. Participants receive either privosegtor or a placebo, both alongside standard steroid treatment. The goal is to see if the drug helps r…

This study tests how well the 2022 International Criteria for Optic Neuritis can diagnose optic neuritis in Chinese patients with sudden vision loss. Researchers will enroll 500 participants and compare the new criteria against expert diagnosis. No experimental treatment is given…

This study aims to find blood-based biomarkers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will experience relapses. Researchers will analyze immune cells from blood samples of 20 children aged 1-18 with a first demyelinating event. The goal …