OLIGODENDROGLIOMA

This early-phase study tests an oral drug called ONC206 in 102 adults with brain tumors that have come back or are rare. The main goal is to find the safest dose and understand side effects. Participants take the drug by mouth on a weekly schedule, and researchers monitor for any…

This study is for adults newly diagnosed with a type of slow-growing brain tumor called oligodendroglioma. The standard treatment is radiation plus chemotherapy, which can harm thinking and quality of life. This trial tests giving a different chemotherapy first, delaying radiatio…

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and can shrink or control relapsed brain tumors in people under 22. About 20 participants with specific types of glioma will receive the treatme…

This study tests a combination of two drugs—ATRA and retifanlimab—in people with a type of brain tumor (glioma) that has come back after standard treatment. The goal is to see if this combination can shrink tumors or slow their growth by boosting the body's immune response. About…

This study tests a drug called safusidenib in adults with a specific type of brain tumor (glioma) that has an IDH1 mutation. The goal is to see if the drug can shrink tumors or slow their growth. The trial has three parts, involving people with different stages of the disease, an…

This study looks at whether delaying radiation therapy can help protect memory and thinking skills in people with a certain type of slow-growing brain tumor (low-grade oligodendroglioma with 1p/19q codeletion). About 280 adults who need treatment beyond surgery will be randomly a…

This study tests whether proton therapy, which targets tumors more precisely than standard photon radiation, is as effective for people with IDH-mutated grade 2 or 3 gliomas. About 225 adults aged 18-65 will be randomly assigned to receive either proton or photon therapy. The mai…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study is testing a program called FearLess to see if it helps people with brain tumors and their caregivers deal with the fear of the cancer coming back. The researchers want to find out if the study methods work well, including how they recruit participants and keep them in…