OLIGODENDROGLIOMA

This study planned to test a two-part experimental treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. The treatment combined a modified virus (Toca 511) designed to enter tumor cells and an extended-release antifungal drug (Toca FC) that the virus helps turn…

This early-stage trial tests a new approach for children whose high-grade glioma has come back after standard treatments. It combines specially grown stem cells with an immunotherapy drug called nivolumab. The main goals are to see if the treatment is safe and possible to deliver…

This early-stage study tests whether combining two drugs—vorasidenib and pembrolizumab—can help people with a specific type of brain tumor (IDH-1 mutant glioma) that has come back or is growing. About 60 adults with grade 2 or 3 tumors will receive the treatment before and after …

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This early study tests a new imaging technique called qOBM that may help brain surgeons see tumor edges more clearly during surgery. About 24 adults with certain brain tumors (glioblastoma, astrocytoma, or oligodendroglioma) will have the device used during their planned tumor re…

This study compares two types of radiation therapy—proton beam and photon beam (IMRT)—to see which one better preserves thinking and memory in people with IDH mutant grade II or III gliomas. About 120 participants will be randomly assigned to one of the two treatments. The goal i…

This study follows 71 people with glioma (a type of brain tumor) to see how radiation therapy affects their thinking skills. Researchers use special brain scans (resting-state fMRI) to map brain networks before and after treatment. The goal is to find which networks are most vuln…