NORMAL PHYSIOLOGY
Clinical trials for NORMAL PHYSIOLOGY explained in plain language.
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Brain layer secrets revealed: how we lock in new skills
Knowledge-focused CompletedThis study looked at how specific layers in the brain's motor area help us learn and remember new movement skills, like typing a sequence. Forty healthy, right-handed adults practiced key sequences and had brain scans to see which layers were active. The goal was to understand th…
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated May 26, 2026 04:06 UTC
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Healthy brains scanned twice to test reliability of imaging tools
Knowledge-focused CompletedThis study looked at how consistent brain scans are when taken twice in the same day. Researchers used MRI and PET scans to map brain connections in 112 healthy adults. The goal was to understand normal brain function patterns, which could help future studies on brain diseases.
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 26, 2026 04:05 UTC
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Could a cooler room help you burn more calories?
Knowledge-focused CompletedThis study looked at how the body burns calories when exposed to different temperatures, from about 61°F to 88°F. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. Healthy men and women stayed in a h…
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated May 26, 2026 04:04 UTC
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Healthy volunteers help unlock secrets of brain stimulation
Knowledge-focused CompletedThis study tested different ways to use noninvasive brain stimulation (like magnetic pulses) in 83 healthy adults aged 18-65. The goal was to learn how to make these techniques more effective for diagnosing and treating brain disorders. Participants completed tasks, had brain sca…
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated May 26, 2026 03:57 UTC
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Scientists scan brains to uncover secrets of schizophrenia
Knowledge-focused CompletedThis study used advanced brain scans (MRI and MEG) to compare the brain structure, chemistry, and activity of people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophrenia, not to test a …
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC
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Brain chemical clues: opioid use disorder and dopamine
Knowledge-focused CompletedThis study looked at how heavy opioid use changes dopamine, a brain chemical that affects pleasure and self-control. Researchers compared people with opioid use disorder (some on medication, some not) to healthy volunteers. They used brain scans and thinking tests to understand t…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 18, 2026 12:11 UTC
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Sleepless nights may leave brain waste behind
Knowledge-focused CompletedThis study looked at how sleep affects the brain's ability to clear out waste products, specifically amyloid-beta, which is linked to Alzheimer's disease. Twenty-two healthy adults stayed overnight in a clinic twice—once sleeping normally and once staying awake all night. Researc…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 18, 2026 12:08 UTC
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Antibiotics may do more than fight infection – new study reveals hidden effects
Knowledge-focused CompletedThis study looked at how two common antibiotics (amoxicillin and azithromycin) change the community of microbes living in healthy people, and whether those changes affect metabolism and the immune system. Over 100 healthy adults took antibiotics for a week or less, and researcher…
Matched conditions: NORMAL PHYSIOLOGY
Phase: PHASE1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated May 05, 2026 11:55 UTC