NON-SMALL CELL LUNG CARCINOMA

This study tests a vaccine made from lung cancer cells, combined with an immune-boosting drug (N-803), in people who have had surgery for non-small cell lung cancer and whose tumors are PD-L1 negative. The goal is to see if the vaccine can train the immune system to recognize and…

This phase 1 trial tests a vaccine (p53MVA) that trains the immune system to attack cancer cells with a p53 mutation, given together with the immunotherapy drug pembrolizumab (Keytruda). The study includes 11 people with advanced solid tumors like lung, head and neck, liver, kidn…

This study tests a new drug called rilvegostomig (AZD2936) in people with advanced or metastatic non-small cell lung cancer. The drug is designed to boost the immune system's ability to fight cancer by blocking two targets (TIGIT and PD-1). The trial will check for safety, side e…

This study tests a new drug called JDQ443 combined with other therapies in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to find safe doses and see if the combinations can shrink or control the cancer. About 74 adults with lun…

This early-phase study tests a combination of two drugs—trastuzumab deruxtecan and pembrolizumab—in people with advanced breast or non-small cell lung cancer that has spread. The goal is to find the safest dose and see if the combo shrinks tumors. About 115 adults with HER2-posit…

This study tests whether adding high-dose vitamin C (ascorbate) to the usual treatment of radiation and chemotherapy can help control non-small cell lung cancer. About 43 participants will receive the vitamin C alongside their standard therapy. The goal is to see if the combinati…

This study tests an online program called BREATHE for women with non-small cell lung cancer. The program uses mindfulness, compassion, and emotional processing to help improve social well-being and reduce distress. About 70 women will participate, and the main goal is to see if t…

This study tests whether adding acupuncture to standard immunotherapy and chemotherapy helps people with advanced non-small cell lung cancer. Sixty participants will receive either real or sham acupuncture alongside their first four treatment cycles. The goal is to see if acupunc…

This study collects blood samples from about 100 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer who are receiving standard treatments. Researchers will measure cancer DNA levels in the blood over time and compare them to tumor changes. The goal is…