NON-SMALL CELL LUNG CANCER (NSCLC)

This phase 2 trial tested a combination of FLT3 ligand immunotherapy (CDX-301) and stereotactic body radiotherapy (SBRT) in 33 adults with advanced non-small cell lung cancer that had worsened after standard treatments. The goal was to see if this approach could slow cancer growt…

This phase 3 trial tested whether combining two immunotherapy drugs, atezolizumab and tiragolumab, works better than the standard drug durvalumab in people with stage III lung cancer that cannot be removed by surgery. All 829 participants had already received chemotherapy and rad…

This phase 2 trial tested a combination of the immunotherapy drug pembrolizumab and a personalized 4-week course of radiotherapy in 25 patients with advanced non-small cell lung cancer whose tumors had high PD-L1 levels. The goal was to see if this approach could control the canc…

This study tested a new combination of drugs (tiragolumab plus atezolizumab and chemotherapy) against the current standard treatment (pembrolizumab plus chemotherapy) in 542 people with advanced non-squamous lung cancer who had not been treated before. The goal was to see if the …

This study tested the drug osimertinib in 73 adults with a specific type of lung cancer (EGFR mutation-positive) that had spread to the lining of the brain. The goal was to see if the drug could shrink these tumors and help patients live longer. Participants took one pill daily, …

This early-phase trial tested a new way to treat advanced cancers that have spread. It combined a special type of radiation with two immunotherapy drugs (MEDI4736 and tremelimumab) to see if the combination is safe and tolerable. The study included 53 adults with advanced melanom…

This study tested an oral targeted medicine called capmatinib in 36 Chinese adults with advanced non-small cell lung cancer that has a specific MET gene change (exon 14 skipping). The goal was to see if the drug could shrink or control tumors safely. Participants had not received…

This study tested whether changing how FDG PET/CT scans are taken and processed can make them more accurate for staging lung cancer. Thirty adults with non-small cell lung cancer were enrolled. The goal was to see if better imaging could help doctors determine if cancer has sprea…

This completed study from Argentina looked at 70 patients with resectable non-small cell lung cancer who received nivolumab (Opdivo) plus chemotherapy before surgery. Researchers wanted to see how well this combination works in real-world practice, measuring how many patients had…

This study tested whether small devices called Calypso beacons, placed near lung tumors, can help doctors track the tumor's position during radiation while the patient holds their breath. 48 adults with lung cancer took part. The goal was to see if this approach is feasible and t…