Non-cystic fibrosis bronchiectasis

This phase 2 trial is testing whether an experimental biologic drug called galvokimig can delay the first moderate or severe lung infection (pulmonary exacerbation) in adults with non-cystic fibrosis bronchiectasis, a chronic lung condition that causes coughing, mucus buildup, an…

This study tests an inhaled drug called ensifentrine in 284 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. Participants will receive either the drug or a placebo twice daily for at least 24 weeks. The goal …

This early-stage trial tests an inhaled drug called Rev-56 in healthy volunteers and in people with non-cystic fibrosis bronchiectasis who have chronic Pseudomonas aeruginosa lung infections. The study checks whether the drug is safe and how the body processes it, comparing Rev-5…

This study tests whether a device called SIMEOX, used at home with remote physiotherapy, can improve quality of life and reduce lung infections in people with bronchiectasis (a chronic lung disease with mucus buildup). About 622 adults will use the device daily or get standard ca…

This study tests the safety of a drug called HSK31858 in 669 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes repeated infections and breathing problems. Participants who completed a prior study of the same drug will receive the medication and be monit…

This study tests an inhaled medicine called CSL787 in adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. The goal is to see if CSL787 can delay the time until a person's next lung flare-up (exacerbation) compar…

This early-stage study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, like non-CF bronchiectasis and COPD. The main goal is to check if the drug is safe and tolerable. About 128 adults with stable disease and good lung function will t…

This study tests whether a home-based breathing and respiratory muscle training program, supported by a health coach, can help people with non-cystic fibrosis bronchiectasis improve their exercise ability and lung function. About 50 participants will use a digital program at home…

This observational study is developing a computer model to identify different types of bronchiectasis in adults. Researchers will collect health data from 750 participants over time to see if they can predict disease patterns. No treatments or interventions are given; participant…

This study is creating a new scoring system called BASE to measure how severe bronchiectasis is and predict the chance of a flare-up over the next year. Researchers will follow 750 adults with non-cystic fibrosis bronchiectasis for 12 months, collecting routine medical data. No n…