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New inhaled drug aims to keep bronchiectasis patients Flare-Up free

NCT ID NCT07048262

Disease control Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an inhaled medicine called CSL787 in adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. The goal is to see if CSL787 can delay the time until a person's next lung flare-up (exacerbation) compared to a placebo. About 450 adults aged 18 to 85 will take part, receiving either one of two doses of CSL787 or a placebo via a nebulizer for up to 12 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 450 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult between the ages of 18 to 85 years * Primary diagnosis of NCFB confirmed by chest computed tomography (CT) scan, where bronchiectasis has been documented by a radiologist. Diagnosis in the medical records based on historical scans is acceptable if the chest CT scan confirming the participant's NCFB diagnosis was performed within 12 months before enrollment. Participants for whom no chest CT scan results are available within the previous 12 months will undergo a chest CT scan during the Screening Period * Exacerbation history within the previous 1 year defined as either 1 of the following: * \>= 2 documented exacerbations requiring oral and/or intravenous (IV) antibiotic therapy to treat a pulmonary infection. OR * 1 documented exacerbation requiring oral and/or IV antibiotic therapy to treat a pulmonary infection and a St. George's Respiratory Questionnaire (SGRQ) Symptoms score of \> 40 at Screening. * Note: Other medications to treat NCFB such as: oral macrolides, or dipeptidyl peptidase-1 (DPP-1) inhibitors are allowed, provided \>= 1 historical exacerbation occurred while on the medication for \>= 3 months at a stable dose. * Postbronchodilator percentage of the predicted normal forced expiratory volume in 1 second of expiration \[FEV1% predicted\] \> 35% and forced expiratory volume in 1 second (FEV1) \>= 1 liter (L) obtained in accordance with American Thoracic Society (ATS) / European Respiratory Society (ERS) standards for spirometry during Screening and at Baseline. Exclusion Criteria: * History of bronchospasm in response to inhaled therapies including inhaled antibiotics * Known or suspected hypersensitivity, or other severe reactions, to the investigational product (IP), to any excipients of the IP, or to other immunoglobulin. * Primary diagnosis of other pulmonary disorders, including chronic obstructive pulmonary disease (COPD) asthma or, diffuse panbronchiolitis (DPB), as determined by the investigator. * Pulmonary exacerbation requiring antibiotic therapy within the 4 weeks before Baseline.

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Conditions

The condition(s) this trial relates to.

bronchiectasis Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-cystic fibrosis bronchiectasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fukuoka University Chikushi Hopsital

    RECRUITING

    Chikushino-shi, Japan

  • Ibaraki Prefectural Central Hospital

    RECRUITING

    Ibaraki, Japan

  • Japan Anti-Tuberculosis Association, Fukujuji Hospital

    RECRUITING

    Tokyo, Japan

  • Kazunori Tobino Iizuka Hospital

    RECRUITING

    Iizuka-shi, Japan

  • Keio University Hospital

    RECRUITING

    Tokyo, Japan

  • Kyusho Central Hospital of the Mutual Aid Association of Public School Teachers

    RECRUITING

    Fukuoka, Japan

  • Matsusaka Municipal Hospital

    RECRUITING

    Mie, Japan

  • National Hospital Organization Kinki Chuo Chest Medical Center

    RECRUITING

    Osaka, Japan

  • National Hospital Organization Mie Chuo Medical Center

    RECRUITING

    Tsu, Japan

  • National Hospital Organization Minami Kyoto Hospital

    RECRUITING

    Kyoto, Japan

  • Shimonoseki City Hospital

    RECRUITING

    Shimonoseki-shi, Japan

  • The Prince Charles Hospital

    RECRUITING

    Queensland, Australia

  • Westmead Hospital

    RECRUITING

    Westmead, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.