NEUROFIBROMATOSIS 1
Clinical trials for NEUROFIBROMATOSIS 1 explained in plain language.
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Could a daily pill shrink painful NF1 tumors? new global trial seeks answers.
Disease control OngoingThis study tests the drug selumetinib in adults with neurofibromatosis type 1 (NF1) who have painful, inoperable nerve tumors called plexiform neurofibromas. About 145 participants worldwide will receive either selumetinib or a placebo to see if the drug can shrink tumors and red…
Matched conditions: NEUROFIBROMATOSIS 1
Phase: PHASE3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated May 26, 2026 11:19 UTC
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New hope for NF1 patients: targeted drug shrinks inoperable tumors in early trial
Disease control OngoingThis early-stage study tests the safety and effectiveness of selumetinib, a drug that blocks a key cancer growth signal, in 32 Chinese children and adults with neurofibromatosis type 1 (NF1) who have inoperable plexiform neurofibromas (nerve tumors). Participants take the drug by…
Matched conditions: NEUROFIBROMATOSIS 1
Phase: PHASE1 • Sponsor: AstraZeneca • Aim: Disease control
Last updated May 26, 2026 11:17 UTC
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Promising drug may shrink inoperable tumors in kids with rare genetic condition
Disease control OngoingThis study tests a drug called selumetinib in children and young adults (ages 3-18) with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink the tumors or stop them from growing. Participants take the d…
Matched conditions: NEUROFIBROMATOSIS 1
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 11:07 UTC
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Could a Fat-Dissolving drug shrink NF1 skin tumors? new trial aims to find out
Symptom relief ENROLLING_BY_INVITATIONThis early-phase trial tests whether monthly injections of Kybella (a drug already approved for fat reduction) can safely shrink cutaneous neurofibromas—small, benign skin tumors—in people with Neurofibromatosis Type 1. Up to 15 adults will receive up to 6 monthly treatments, wit…
Matched conditions: NEUROFIBROMATOSIS 1
Phase: PHASE1 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 26, 2026 11:23 UTC
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Could kitchen staples shrink NF1 tumors? new study tests olive oil and curcumin
Symptom relief OngoingThis early-phase study is testing whether a combination of high-phenolic extra virgin olive oil and curcumin is safe and can help reduce skin tumors in adults with neurofibromatosis type 1 (NF1). Twenty-three participants take the supplements twice daily for up to 12 months. The …
Matched conditions: NEUROFIBROMATOSIS 1
Phase: PHASE1 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Symptom relief
Last updated May 26, 2026 11:19 UTC
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New study aims to predict cancer in NF1 patients before it starts
Knowledge-focused OngoingThis study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans and blood samples to track changes in nerve tumors. The goal is to find imaging …
Matched conditions: NEUROFIBROMATOSIS 1
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated May 26, 2026 11:24 UTC
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New blood test could spot NF1 tumors without Full-Body scans
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks for substances in the blood that could signal the presence of plexiform neurofibroma tumors in people with Neurofibromatosis type 1 (NF1). Researchers will collect blood samples and use whole-body MRI scans from 200 participants to see if certain biomarkers match…
Matched conditions: NEUROFIBROMATOSIS 1
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Knowledge-focused
Last updated May 26, 2026 11:22 UTC
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500 NF1 patients join 5-year skin tumor watch
Knowledge-focused OngoingThis study follows 500 people with neurofibromatosis type 1 (NF1) to see how their skin tumors (cutaneous neurofibromas) grow and change over five years. Researchers use 3D cameras to track tumors and study genetic links. The goal is to better understand these tumors to help doct…
Matched conditions: NEUROFIBROMATOSIS 1
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC