NEURO-DEGENERATIVE DISEASE

This study tests a drug called cobimetinib in children and adults with Langerhans cell histiocytosis (LCH) and related disorders that have not responded to standard treatment. Cobimetinib blocks a faulty growth signal in the cells causing the disease. The goal is to shrink tumors…

This study tests whether custom 3D-printed cutlery handles can help elderly patients with neurodegenerative diseases eat more independently. About 75 people in continuing care will try handles sized to their grip. The goal is to see if these lightweight, low-cost tools improve ea…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study looks at the experiences of extended family members—like grandchildren, siblings, and nieces/nephews—who care for a loved one with dementia. Researchers will interview 240 caregivers about their daily tasks, stress, and the support they use or need. The goal is to find…

This study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will check participants once a year to see how the disease progresses. The goal is to learn more about the condition and find better ways to measure it in future studies.