NEOPLASMS BY SITE

This study is testing whether a new drug, PF-08634404, works better than the current standard treatment for people whose colorectal cancer has spread. About 800 adults who haven't yet received treatment for their advanced cancer will be randomly assigned to get either the new dru…

This trial is testing if a drug called alectinib, already approved for a type of lung cancer, can help treat other rare cancers that share the same genetic change (ALK mutation). It will involve about 30 adults and children with various rare or hard-to-treat cancers. The goal is …

This study is testing a new drug called Pocenbrodib to see if it is safe and can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. Researchers will give Pocenbrodib alone or combined with other cancer drugs to about …

This study is testing whether giving two immunotherapy drugs before surgery can shrink bladder tumors enough to avoid removing the bladder entirely. The trial will enroll 90 adults with muscle-invasive bladder cancer who are not receiving standard chemotherapy. Researchers will c…

This trial is testing if a drug called capmatinib, already used for some lung cancers, can help adults with rare or uncommon cancers that have specific changes in a gene called MET. The goal is to see if the drug shrinks tumors or provides long-term benefit for these hard-to-trea…

This trial is testing if an existing immunotherapy drug called atezolizumab can help control rare cancers or common cancers with rare genetic features. It will involve about 30 adults and children whose cancers have specific genetic markers. The goal is to see if this approved dr…

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This study is testing whether two drugs, elacestrant and abemaciclib, work together to control breast cancer that has spread to the brain. It will involve about 73 adults whose cancer is fueled by estrogen and has spread to the brain. The first part finds the safest dose, and the…

This study is observing how well a robotic system works in real hospitals to help doctors locate and take samples from suspicious spots in the lungs. It will follow 3,000 patients who are already scheduled to have this robotic-assisted biopsy procedure. The main goal is to see ho…