NEOPLASMS BY SITE

This program gives adults with advanced or spreading ROS1-positive non-small cell lung cancer access to taletrectinib when they cannot use approved treatments or join ongoing studies. It is for patients who, in their doctor's opinion, might benefit from the drug. The goal is to p…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who have not had prior therapy. The goal is to me…

This study tests a new drug, savolitinib, against a standard treatment, sunitinib, for people with a specific type of advanced kidney cancer called MET-driven papillary renal cell carcinoma. The goal is to see if savolitinib works better at slowing cancer growth and to check its …

This study compares two treatments for early-stage oropharyngeal (throat) cancer: robotic surgery or radiation therapy. The goal is to see which approach leads to better swallowing function and overall quality of life. About 138 patients will be randomly assigned to one of the tw…

This study looks at how well the Ion Endoluminal System works in everyday medical practice for taking tissue samples from lung spots or nodules. About 1,300 adults who need a lung biopsy or lesion localization will be observed. The goal is to see how often the system correctly di…

This study looks at whether educating doctors in small and mid-sized city hospitals about standard guidelines helps improve testing and treatment for people with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more get the right molecular tests…