NARCOLEPSY TYPE 1

This study looks at the long-term safety and effects of a drug called ORX750 in people with narcolepsy (types 1 and 2) or idiopathic hypersomnia. About 90 participants who finished a previous ORX750 trial will take the drug openly for an extended period. Researchers will monitor …

This study looks at the long-term safety and how well the drug ALKS 2680 works for people with narcolepsy type 1, type 2, or idiopathic hypersomnia. It is for those who have already finished a related earlier study. Participants will take ALKS 2680 tablets and be monitored for si…

This study tests the long-term safety of the drug TAK-861 in 500 people with type 1 narcolepsy who have already taken it in earlier trials. Researchers will monitor side effects and measure how well patients can stay awake. The goal is to see if the drug remains safe and effectiv…

This study tests a new drug called ORX750 (cleminorexton) that mimics a natural brain protein, orexin, which helps keep people awake. It is for adults with narcolepsy type 1, type 2, or idiopathic hypersomnia who struggle with severe daytime sleepiness. The goal is to see if the …

This study tests a new tablet called ALKS 2680 in 150 adults with narcolepsy type 1, a condition causing severe daytime sleepiness and sudden muscle weakness. Participants will receive either the study drug or a placebo for 12 weeks. The goal is to see if the drug helps people st…

This study tests an experimental tablet called ALKS 2680 in 150 adults with narcolepsy type 1, a condition causing severe daytime sleepiness and sudden muscle weakness (cataplexy). Participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the…

This study aims to find out how many people in Spain have been diagnosed with narcolepsy type 1 or type 2, and how many new cases are diagnosed each year. Researchers will review medical records from hospitals across Spain to count patients and understand patterns. The study does…

This study looks at whether people with idiopathic REM sleep behavior disorder (iRBD) experience more pain than those with narcolepsy and RBD. iRBD is a strong early sign of Parkinson's disease, but pain in these patients has not been studied before. Researchers will compare pain…

This study looks at whether gut bacteria and bacterial leakage into the blood and spinal fluid play a role in type 1 narcolepsy, a rare sleep disorder. Researchers will compare 120 people with and without narcolepsy to understand how gut health might trigger the immune system to …