NAFLD

This study follows 200 adults with nonalcoholic fatty liver disease (NAFLD) who receive an intragastric balloon—a device placed in the stomach to help with weight loss. Researchers will measure changes in weight, body mass index, blood sugar, cholesterol, and liver health over at…

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have received a liver transplant and have poorly controlled diabetes. The goal is to see which drug better improves blood sugar control and reduces body weight. Participants will take one …

This study tests an experimental drug called efinopegdutide in 80 adults with liver scarring (cirrhosis) caused by a type of fatty liver disease (MASH). The goal is to see if the drug can lower liver fat, inflammation, and scarring over about 7 months. Participants will receive e…

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 adults with moderate to severe liver scarring will take either the drug or a placebo daily for three years. The goal is …

This study tests whether an 8-week very low-calorie diet (800-960 calories per day) can reduce liver fat and scarring in 20 adults with obesity and non-alcoholic fatty liver disease (NAFLD). Participants are randomly assigned to the diet or a lower-calorie control group. The goal…

This study was designed to test a new device that uses sound and heat to measure fat in the liver. It would compare the device's accuracy to standard MRI scans in adults with or suspected of having non-alcoholic fatty liver disease. The goal was to see if this simpler method coul…

This study tests a new portable device called LiverScope that uses simplified MRI technology to measure fat in the liver without needles or surgery. About 50 adults with known or suspected fatty liver disease will have a one-time scan with LiverScope, a standard MRI, and optional…

This study tests new MRI and ultrasound techniques to measure liver fat in children aged 10-14, both with obesity and healthy weight. The goal is to see if these imaging methods work well and are practical for diagnosing non-alcoholic fatty liver disease (NAFLD) without invasive …

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will use a special ultrasound scan to measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to fill a knowledge gap, since past studies on fatty liver hav…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses over time. Researchers use non-invasive scans to measure liver fat and stiffness at the start and after one year. The goal is to fill major knowledge gaps, since people with HI…