MYELOFIBROSIS
Clinical trials for MYELOFIBROSIS explained in plain language.
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Experimental pill tested against seven rare blood diseases
Disease control CompletedThis study tested whether an oral medication called dasatinib could help control several rare blood cancers and disorders. Sixty-eight adults with conditions like acute myeloid leukemia, myelofibrosis, and mastocytosis took the pill daily for as long as it worked. Researchers mea…
Matched conditions: MYELOFIBROSIS
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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New pill aims to shrink spleens and ease symptoms in tough blood cancers
Disease control CompletedThis study tested an experimental pill called pelabresib, both alone and combined with an existing drug (ruxolitinib), for people with myelofibrosis and other blood cancers. The main goals were to find a safe dose and see if the treatment could reduce spleen size, ease symptoms l…
Matched conditions: MYELOFIBROSIS
Phase: PHASE1, PHASE2 • Sponsor: Constellation Pharmaceuticals • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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New drug combo tested for aggressive blood cancers
Disease control CompletedThis study tested a combination of two drugs, ruxolitinib and CPX-351, for people with advanced forms of certain blood cancers. The main goals were to find the safest dose of the combination and to see how well it worked to control the disease. The treatment aimed to reduce cance…
Matched conditions: MYELOFIBROSIS
Phase: PHASE1, PHASE2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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Gentler transplant strategy tested for tough blood cancers
Disease control CompletedThis study tested a two-step, lower-intensity stem cell transplant for patients with high-risk blood cancers like leukemia and lymphoma. The goal was to control the cancer by first using low-dose chemotherapy and radiation to prepare the body, then infusing donor stem cells to at…
Matched conditions: MYELOFIBROSIS
Phase: PHASE2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Apr 02, 2026 14:56 UTC
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One donor, two transplants: experimental procedure aims to cure blood cancer and fix kidneys
Disease control CompletedThis pilot study tested a combined transplant from a partially matched family donor. It aimed to treat patients who had both a serious blood disorder (like leukemia) and advanced kidney disease at the same time. The goal was to cure the blood disorder and restore kidney function …
Matched conditions: MYELOFIBROSIS
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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New drug tested for tough blood cancer cases
Disease control CompletedThis study tested a drug called itacitinib for people with a serious bone marrow cancer called myelofibrosis who had already tried other standard treatments. The main goals were to find a safe dose and see if the drug could reduce spleen size and improve symptoms. Only four peopl…
Matched conditions: MYELOFIBROSIS
Phase: PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Mar 09, 2026 14:26 UTC
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Researchers look back at how doctors treated blood cancer patients
Knowledge-focused CompletedThis study looked back at medical records of 355 myelofibrosis patients in Turkey who were treated with the drug ruxolitinib. Researchers collected information about patient characteristics, treatment approaches, and outcomes between 2015 and 2022. The goal was to understand how …
Matched conditions: MYELOFIBROSIS
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Apr 03, 2026 19:40 UTC
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First step: scientists test new blood disorder Drug's safety with common meds
Knowledge-focused CompletedThis early-stage study aimed to understand how a potential new drug for myelofibrosis (a bone marrow disorder) interacts with other common medications that can speed up or slow down drug processing in the body. It involved 40 healthy volunteers who received single doses of the st…
Matched conditions: MYELOFIBROSIS
Phase: PHASE1 • Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC