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New hope for myelofibrosis patients after standard treatments fail

NCT ID NCT04629508

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 23 times

Summary

This study tested a drug called itacitinib in people with myelofibrosis (a serious bone marrow disease) who had already been treated with ruxolitinib or fedratinib. The goal was to see if itacitinib is safe and can shrink an enlarged spleen, a common problem in this condition. Only 4 people took part, and the study is now complete.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AZ DELTA

    Roeselare, 08800, Belgium

  • Aou San Giovanni Di Dio E Ruggi

    Salerno, 84131, Italy

  • Baptist Cancer Center

    Memphis, Tennessee, 38120, United States

  • Chu Ucl Namur University Hospital Mont-Godinne

    Yvoir, 05530, Belgium

  • Cliniques Universitaires Ucl Saint-Luc

    Brussels, 01000, Belgium

  • Hospital Universitari I Politecnic La Fe

    Valencia, 46000, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Interne 1 - Hematologie Mit Stammzelltransplantation, Hemostaseologie Und Medizinische Onkologie Ord

    Linz, 70376, Austria

  • Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele

    Milan, 20132, Italy

  • Jessa Ziekenhuis

    Hasselt, 03500, Belgium

  • Midamerica Cancer Care

    Kansas City, Missouri, 64114, United States

  • New Jersey Hematology Oncology Associates Llc

    Brick, New Jersey, 08724-3009, United States

  • Pratia Hematologia Katowice

    Katowice, 40-519, Poland

  • Rcca Md, Llc

    Bethesda, Maryland, 20817, United States

  • Renovatio Clinical Consultants Llc

    Spring, Texas, 77380, United States

  • Texas Oncology - Baylor Sammons Cancer Center

    Dallas, Texas, 75246-2092, United States

  • Treviso Hospital

    Treviso, 31100, Italy

  • Tulane University

    New Orleans, Louisiana, 70112, United States

  • Universitaetsmedizin Greifswald

    Greifswald, 17475, Germany

  • Universitatsklinikum Halle (Saale)

    Halle, 06120, Germany

  • Vanderbilt University

    Nashville, Tennessee, 37235, United States

Conditions

Explore the condition pages connected to this study.