MYELODYSPLASTIC SYNDROME (MDS)
Clinical trials for MYELODYSPLASTIC SYNDROME (MDS) explained in plain language.
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New hope for tough blood cancers: experimental drug PRT2527 tested in early trial
Disease control CompletedThis early-stage study tested a new drug called PRT2527, alone or combined with other medicines (zanubrutinib or venetoclax), in 86 people with blood cancers that returned or didn't respond to standard treatments. The main goals were to check safety, find the best dose, and see i…
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: PHASE1 • Sponsor: Prelude Therapeutics • Aim: Disease control
Last updated May 22, 2026 14:05 UTC
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Supercharged cord blood transplant shows promise for faster recovery in blood cancer patients
Disease control CompletedThis study tested a special stem cell product called NiCord, made by growing cord blood cells in a lab to increase their number. It was compared to standard cord blood transplants in 125 people with blood cancers like leukemia and lymphoma. The goal was to see if NiCord could hel…
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: PHASE3 • Sponsor: Gamida Cell ltd • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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One donor, two transplants: new hope for patients with blood cancer and kidney failure
Disease control CompletedThis study tested a combined bone marrow and kidney transplant from a partially matched family donor for 10 people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one donor, potentially reducing the need for lifelong anti-…
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated May 18, 2026 12:01 UTC
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New drug combo shows promise for rare blood cancers
Disease control CompletedThis study tested a new pill called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. The goal was to see if it could shrink enlarged spleens and reduce the need for blood transfusions. The drug was given alone or with another medicine (ruxoli…
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: PHASE1, PHASE2 • Sponsor: Constellation Pharmaceuticals • Aim: Disease control
Last updated May 08, 2026 12:01 UTC
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First human test of LP-001: safety check in healthy people
Knowledge-focused CompletedThis early-stage study tested a new drug called LP-001 in 68 healthy adults aged 18 to 50. The main goal was to see if it is safe and how the body processes it. No direct treatment was given; results will help plan future studies for people with myelodysplastic syndrome.
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: PHASE1 • Sponsor: Longbio Pharma • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Kidney function and race may change drug dosing in stem cell transplants
Knowledge-focused CompletedThis study looked at how kidney function and race/ethnicity affect the drug treosulfan in 20 people with AML or MDS getting a stem cell transplant. The goal was to find safe doses for those with kidney problems. It was a small, early-phase study that did not test a new treatment …
Matched conditions: MYELODYSPLASTIC SYNDROME (MDS)
Phase: PHASE1 • Sponsor: medac GmbH • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC