New hope for tough blood cancers: experimental drug PRT2527 enters human testing
NCT ID NCT05665530
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 21 times
Summary
This early-stage trial tested a new drug called PRT2527, alone or combined with other drugs (zanubrutinib or venetoclax), in 86 people with blood cancers that returned or didn't respond to standard treatments. The main goals were to check safety, find the best dose, and see if the drug shrinks tumors. The study is now complete, and results will guide future research.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alfred Health
Melbourne, Victoria, 3004, Australia
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American Oncology Partners of Maryland, PA
Bethesda, Maryland, 20817, United States
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Austin Health
Heidelberg, Victoria, 3084, Australia
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Centre Léon Bérard
Lyon, 69373 Cedex 08, France
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City of Hope
Duarte, California, 91010, United States
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Claude Huriez Hospital
Lille, 59000, France
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Ente Ospedaliero Cantonale (EOC) lstituto Oncologico della Svizzera italiana (IOSl)- Ospedale San Giovanni (ORBV)
Bellinzona, Canton Ticino, 6500, Switzerland
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Hopital Henri Mondor
Créteil, 94010, France
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IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant'Orsola
Bologna, 40138, Italy
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Institut Curie
Saint-Cloud, 92210, France
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Keimyung_University Dongsan Hospital
Daegu, 42601, South Korea
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Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, 10016, United States
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Linear Clinical Research Ltd
Perth, Western Australia, 6009, Australia
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Monash Health
Melbourne, Victoria, 3168, Australia
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Ospedale Santa Maria delle Croci - AUSL della Romagna
Ravenna, 48121, Italy
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Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Samsung Medical Center
Seoul, 06351, South Korea
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The Leeds Teaching Hospitals NHS Trust, St James University Hospital
Leeds, West Yorkshire, LS9 7TF, United Kingdom
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Universitatsklinikum Koln, Klinik I fur lnnere Medizin
Cologne, North Rhine-Westphalia, 50937, Germany
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University of Virginia Comprehensive Cancer Center
Charlottesville, Virginia, 22903, United States
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lnje University Busan Paik Hospital
Busan, 47392, South Korea
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lstituto Romagnolo per lo Studio dei Tumori "Dino Amadori" IRST
Meldola, FC, 47014, Italy
Conditions
Explore the condition pages connected to this study.