MINIMAL CHANGE DISEASE

This study tests a noninvasive device that gently stimulates a nerve in the ear to help children with steroid-resistant nephrotic syndrome, a kidney condition that doesn't respond to standard steroids. The goal is to see if this approach is safe, tolerable, and can reduce inflamm…

This study tests a new drug called WAL0921 in 96 adults with kidney diseases that cause protein in the urine, including diabetic kidney disease and rare conditions like FSGS. Participants receive either the drug or a placebo as an IV infusion every two weeks for 14 weeks, then ar…

This study tests an experimental drug called sparsentan in 67 children with certain kidney diseases that cause protein leakage in urine. The goal is to see if the drug safely reduces protein levels over 108 weeks. Participants take the drug once daily as a liquid or tablet, and r…

This small pilot study is testing whether a gentle, non-invasive nerve stimulation device worn on the ear can help children with a frequently relapsing kidney disease. The goal is to see if this approach can reduce disease flare-ups and the need for strong steroid medications. Re…

This study is creating a long-term registry of 500 people with two rare kidney conditions: focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Researchers will collect blood, urine, and tissue samples, along with health updates, to learn how these diseases…

This study gathers information and biological samples from 300 people with FSGS or MCD who have had or will have a kidney transplant. Researchers want to learn why these kidney diseases sometimes come back after transplant and how to improve treatment. Participants provide data o…

This study helps people with nephrotic syndrome and related kidney diseases find clinical trials that may be a good fit for their specific condition. Researchers use detailed molecular information from each participant to recommend targeted therapies being tested in other studies…

This study interviews 150 children, adults, and parents about their experiences with swelling caused by Nephrotic Syndrome. Researchers will use the information to create a survey that helps test new medications. No treatment is given; the goal is to better understand symptoms.