MILD AUTONOMOUS CORTISOL SECRETION (MACS)
Clinical trials for MILD AUTONOMOUS CORTISOL SECRETION (MACS) explained in plain language.
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Can a diabetes drug replace surgery for a rare hormone condition?
Disease control Recruiting nowThis study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers will compare adrenalectomy (surgery to remove an adrenal gland) with semaglutide (a weight-management drug) to see which better improv…
Matched conditions: MILD AUTONOMOUS CORTISOL SECRETION (MACS)
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated May 20, 2026 11:57 UTC
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New drug targets hidden hormone problem that affects metabolism
Disease control Recruiting nowThis study tests whether the drug Isturisa can improve health in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers will measure changes in blood sugar, cholesterol, weight, bone density, and quality of life over…
Matched conditions: MILD AUTONOMOUS CORTISOL SECRETION (MACS)
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New study tests which drug better tames cortisol excess
Disease control Recruiting nowThis study compares two medications, metyrapone and osilodrostat, to see which works better and has fewer side effects for people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. About 150 adults with adrenal adenomas or hyperpla…
Matched conditions: MILD AUTONOMOUS CORTISOL SECRETION (MACS)
Phase: PHASE4 • Sponsor: Laikο General Hospital, Athens • Aim: Disease control
Last updated May 11, 2026 20:50 UTC
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New study aims to uncover hidden hormone imbalance in common adrenal tumors
Knowledge-focused Recruiting nowThis study aims to find the best combination of tests to detect mild autonomous cortisol secretion (MACS) in people with adrenal incidentalomas—non-cancerous tumors found by chance on scans. Researchers will enroll 20 adults and compare several diagnostic tests, including blood, …
Matched conditions: MILD AUTONOMOUS CORTISOL SECRETION (MACS)
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated May 26, 2026 11:27 UTC