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Drug showdown: which pill tames cortisol better?

NCT ID NCT07268222

Disease control Sponsor: Laikο General Hospital, Athens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two medications, metyrapone and osilodrostat, in 150 adults with mild autonomous cortisol secretion (MACS). Participants receive one of the drugs, surgery, or watchful waiting. The goal is to see which drug better lowers cortisol and improves related health issues like high blood pressure and blood sugar over 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
metyrapone and osilodrostat (oral tablets)
What this could lead to
If successful, this trial could show which drug better controls cortisol levels and improves blood pressure, weight, and blood sugar in people with mild autonomous cortisol secretion.
What could go wrong
This is a relatively small Phase 4 trial, so results may not apply to everyone. Both drugs can cause side effects like nausea or low cortisol, and the study does not test a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults \> 18 years old with MACS and unilateral or bilateral adrenal adenomas or hyperplasia (based on imaging) * 1 mg overnight dexamethasone suppression test (ODST): Cortisol levels at 8.00 am\>1.8 μg/dl AND i) ACTH\< 15 pg/ml OR ii) abnormal midnight salivary cortisol OR iii) Urinary free cortisol levels (UFC) /24h ≥ of the UNL Exclusion Criteria: * Abnormal liver enzymes * eGFR \< 40 ml/min/1.73 m3 * Pseudocushing syndrome * Patients with any malignancy (active or past history), including ACC * ACTH-dependent Cushing syndrome (Cushing disease or ectopic Cushing syndrome)

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Conditions

The condition(s) this trial relates to.

ACTH-independent Cushing syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild autonomous cortisol secretion (MACS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Laikon General Hospital

    RECRUITING

    Athens, Greece

More trials for these conditions

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