MIGRAINE DISORDERS

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) works better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the best first-…

This study is testing a mind-body program delivered by nurses to help children and teens with migraine have fewer headache days. The program combines different treatment parts to find the best approach. About 260 kids with migraine will take part. The goal is to see if this progr…

This study tests a lifestyle behavior program to help people with chronic migraine reduce how often and how severely their headaches happen. Researchers will also look for biological markers linked to improvement. The goal is to see if the program is practical and liked by partic…

This study looks at whether closing a common heart defect called PFO (a small hole between the upper chambers) can reduce migraine attacks. Researchers will compare 150 adults with PFO—some with migraines and some without—before and after a procedure to close the hole. The goal i…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study is creating a large registry of over 2,000 adults with migraine in Italy. Researchers will collect information from medical records and patient interviews to better understand migraine types, how the disease affects daily life, and what treatments people use. The goal …