Microbiome

This trial tests whether changing from acid-blocking drugs to a stomach-lining protector called teprenone after a stem cell transplant can reduce the risk of acute graft-versus-host disease (aGVHD), a serious complication where donor immune cells attack the recipient's body. Abou…

This study tests whether a high-fiber diet (20-30 grams per day) combined with mind-body support can help women with triple-negative breast cancer undergoing immunotherapy and chemotherapy. Sixty participants will either receive online group training or a simple nutrition flyer. …

This study tests a device called Gixam to see if it can find precancerous growths or colon cancer in people aged 45-84 who had a negative stool test (FIT). About 1,436 participants will use the Gixam device, take a home stool test, and then get a standard colonoscopy. The goal is…

This study is looking at whether analyzing the bacteria in a person's stool can help detect colorectal cancer earlier, especially in people under 50 who are not routinely screened. Researchers will collect stool samples and diet information from 400 adults in Portugal recently di…

This study tests whether a probiotic supplement can improve gut health and reduce symptoms in people with reflux disease (GERD) who are already taking standard medication. Fifty participants will take either the probiotic or a placebo for six weeks. Researchers will check changes…

This study aims to improve early detection of colorectal cancer by analyzing gut bacteria in stool samples from 30,000 people in Portugal aged 40-74. Researchers will compare the microbiome of healthy individuals with those who have precancerous polyps or cancer, looking for uniq…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study looks at the types of germs and their resistance genes in 800 people with pneumonia. Researchers will compare severe and mild cases to understand which microbes and resistance patterns are most common. The goal is to improve how doctors diagnose and treat pneumonia, es…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study explores whether the natural bacteria in your gut affect diarrhea caused by the breast cancer drug abemaciclib. Researchers will compare stool samples from 60 women who get diarrhea with those who don't. No new treatments are given—just observation to learn why some pe…

This study looks at how different oral hygiene routines (including mouthwash) affect gum health, mouth bacteria, and inflammation in people with gingivitis. About 250 adults will use assigned products twice daily for 4 weeks, then stop for 2 weeks to see how their gums and microb…

This study enrolls 250 infants born by C-section to see if personalized diet and probiotic advice can improve their gut bacteria and reduce early signs of eczema. Babies provide stool samples over two years, and parents get tailored recommendations based on their baby's microbiom…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study looks at the bacteria living in the mouth and gut of people who may have pancreatic cancer. Researchers want to see if certain germs can help spot the disease earlier or predict how well a patient will do. About 300 adults with a suspicious spot on their pancreas will …

This early-phase trial tests whether it is safe and practical to swab the noses of C-section babies with maternal vaginal secretions. The goal is to see if this can modify the baby's respiratory microbiome. Twenty healthy newborns will be randomly assigned to receive either the v…

This study looks at how different sweeteners in drinks change the acidity in the mouth and the bacteria in dental plaque. About 52 Mexican teenagers who regularly drink soda will try plain water, water with stevia, and water with sugar. Researchers will measure changes in saliva …

This study follows 600 burn patients and 60 healthy people over two years to see how burns change the community of microbes on the skin and in the gut. Researchers will collect swabs, stool, and blood samples at several time points to map these changes. The goal is to better unde…