Can a swab of Mom's fluids boost C-Section Babies' microbiome?
NCT ID NCT05505110
First seen Nov 10, 2025 · Last updated Jun 22, 2026 · Updated 31 times
Summary
This early-phase trial tests whether it is safe and practical to swab the noses of C-section babies with maternal vaginal secretions. The goal is to see if this can modify the baby's respiratory microbiome. Twenty healthy newborns will be randomly assigned to receive either the vaginal seeding or a sterile swab. The study focuses on feasibility and safety, not yet on health outcomes.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
maternal vaginal secretions
What this could lead to
If successful, this could pave the way for larger studies exploring whether vaginal seeding helps restore the respiratory microbiome in C-section babies.
What could go wrong
This is a very early, small feasibility trial with only 20 participants. It is not designed to prove health benefits, and safety monitoring is a primary focus.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.