Can a swab of Mom's fluids boost C-Section Babies' microbiome?

NCT ID NCT05505110

Recruiting now Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests whether it is safe and practical to swab the noses of C-section babies with maternal vaginal secretions. The goal is to see if this can modify the baby's respiratory microbiome. Twenty healthy newborns will be randomly assigned to receive either the vaginal seeding or a sterile swab. The study focuses on feasibility and safety, not yet on health outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: maternal vaginal secretions
What this could lead to: If successful, this could pave the way for larger studies exploring whether vaginal seeding helps restore the respiratory microbiome in C-section babies.
What could go wrong: This is a very early, small feasibility trial with only 20 participants. It is not designed to prove health benefits, and safety monitoring is a primary focus.

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Conditions

The condition(s) this trial relates to.

respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C-SECTION MICROBIOME RESPIRATORY VAGINAL SEEDING

Contacts and locations

Locations

Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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