METHAMPHETAMINE ABUSE

This study tests whether a long-term, high-dose prescription stimulant (lisdexamfetamine) can help people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 participants will receive either the drug or a placebo alongside standard care…

This study tests whether a low dose of ketamine, given through an IV, can help people reduce or stop using methamphetamine. It involves 120 adults with moderate to severe methamphetamine use disorder. Participants will receive either ketamine or a placebo (midazolam) over six wee…

This study tests whether adding a high-dose stimulant medication and a rewards program (contingency management) to usual care helps adults reduce their methamphetamine use. 440 participants will be randomly assigned to one of four groups for 15 weeks. The goal is to see which com…

This study tests a new medicine called CS-1103 in 40 healthy adults who use methamphetamine but are not looking for treatment. The goal is to see if CS-1103 can safely reduce the drug's effects and help the body get rid of meth faster. Participants receive a single dose of metham…

This study tests whether a combination of two medications, extended-release naltrexone and bupropion, can help people with moderate to severe methamphetamine use disorder reduce their drug use. About 360 adults who want to cut back or quit will receive either the medication or a …

This study tests two types of reward programs to help people with opioid, cocaine, or methamphetamine use disorders stay abstinent. Participants use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to find the b…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults with methamphetamine use disorder who are in treatment. Participants will do computer tasks and have brain scans before and after recalling a happy memory or a neutral one. The …