METASTATIC MALIGNANT NEOPLASM

This study tests whether freezing tumors with a probe (cryoablation) can boost the effects of standard immunotherapy in people with metastatic cancer. About 15 participants will receive cryoablation on some of their tumors while continuing their usual immunotherapy. The goal is t…

This study tests a drug called talazoparib in 150 adults whose advanced cancer has stopped responding to standard treatments. The drug works by blocking an enzyme that helps tumor cells survive, and is given to people whose tumors have specific changes in BRCA or related genes. T…

This study compares two radiation treatments for people whose cancer has spread to the brain (but not from melanoma). One is stereotactic radiosurgery, which targets tumors precisely with a high dose. The other is whole brain radiation, which treats the entire brain with lower do…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce cancer-related fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethason…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in advanced cancer patients in a palliative care unit. About 70 participants will receive the drugs and be monitored for 24 hours. The goal is …

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in advanced cancer patients in palliative care. About 110 patients whose symptoms don't improve with low-dose haloperidol will receive different drug strategie…

This study looks at whether a medication called methylphenidate (often used for ADHD) combined with physical activity can help reduce severe tiredness in people with advanced cancer who are receiving immunotherapy. About 212 patients with metastatic cancer will take part. The goa…

This study looks at whether cancer patients and their caregivers prefer to wait in an exam room or a waiting room when they visit a supportive care clinic. Researchers will ask about their preferences to understand how to make visits more comfortable. About 406 people with advanc…

This study looks at whether analyzing the genetic changes in a patient's tumor can help doctors pick a more effective targeted therapy for metastatic cancer. Over 1,300 patients with advanced cancer that has spread are randomly assigned to receive either a treatment chosen based …

This study looks at how serious money problems are for people with advanced cancer. Cancer care can be very expensive, and the stress from debt and high costs may make physical symptoms and quality of life worse. About 141 patients will fill out a short survey to measure their fi…